2. Gene
  3. PPP4R1 - protein phosphatase 4 regulatory subunit 1 Gene

PPP4R1 - protein phosphatase 4 regulatory subunit 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as MEG1; PP4R1; PP4(Rmeg)

Gene ID: 9989 | Gene type: protein coding

About PPP4R1

Cytogenetic location: 18p11.22 Genomic coordinates (GRCh38): 18:9,546,794-9,617,199 (from NCBI)

This gene has 29 transcripts (splice variants), 169 orthologues and 2 paralogues. Ubiquitous expression in esophagus (RPKM 39.0), testis (RPKM 25.5) and 25 other tissues.

Summary

This gene encodes one of several alternate regulatory subunits of serine/threonine protein Phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from Other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

PPP4R1 Products(3)

mRNA Protein Name
NM_001042388.3 NP_001035847.1 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform a
NM_001382562.1 NP_001369491.1 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform c
NM_005134.4 NP_005125.1 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform b

PPP4R1 Protein Structure

HEAT

HEAT: HEAT repeat (253 - 279)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 950 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 4 regulatory subunit 1

serine/threonine phosphatase 4

PPP4R1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PPP4R1 Q8TF05 PPP4C Homo sapiens P60510
Anti Bait CoIP
18614045
Intra
PPP4R1 Q8TF05 PPP4C Homo sapiens P60510
Anti Tag CoIP
26496610
Intra
PPP4R1 Q8TF05 PPP4C Homo sapiens P60510
Anti Tag CoIP
18715871
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11029 PPP4R1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PPP4R1 VGNC VGNC:33269
Macaca mulatta PPP4R1 VGNC VGNC:104233
Felis catus PPP4R1 VGNC VGNC:69023
Rattus norvegicus PPP4R1 RGD RGD:619798
Canis familiaris PPP4R1 VGNC VGNC:53875
Mus musculus PPP4R1 MGD MGI:1917601