PPP4R1 - protein phosphatase 4 regulatory subunit 1 Gene

Homo sapiens

Also known as MEG1; PP4R1; PP4(Rmeg)

Gene ID: 9989 | Gene type: protein coding

About PPP4R1

Cytogenetic location: 18p11.22 Genomic coordinates (GRCh38): 18:9,546,794-9,617,199 (from NCBI)

This gene has 29 transcripts (splice variants), 169 orthologues and 2 paralogues. Ubiquitous expression in esophagus (RPKM 39.0), testis (RPKM 25.5) and 25 other tissues.

Summary

This gene encodes one of several alternate regulatory subunits of serine/threonine protein Phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

PPP4R1 Products(3)

mRNA	Protein	Name
NM_001042388.3	NP_001035847.1	serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform a
NM_001382562.1	NP_001369491.1	serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform c
NM_005134.4	NP_005125.1	serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform b

PPP4R1 Protein Structure

HEAT

0
200
400
600
800
950 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 4 regulatory subunit 1

serine/threonine phosphatase 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11029	PPP4R1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPP4R1	VGNC	VGNC:33269
Macaca mulatta	PPP4R1	VGNC	VGNC:104233
Felis catus	PPP4R1	VGNC	VGNC:69023
Rattus norvegicus	PPP4R1	RGD	RGD:619798
Canis familiaris	PPP4R1	VGNC	VGNC:53875
Mus musculus	PPP4R1	MGD	MGI:1917601

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