PPP4C - protein phosphatase 4 catalytic subunit Gene

Homo sapiens

Also known as PP4; PPX; PP-X; PP4C; PPH3; PPP4

Gene ID: 5531 | Gene type: protein coding

About PPP4C

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,075,994-30,085,376 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 31.5), placenta (RPKM 25.7) and 25 other tissues.

Summary

Enables protein serine/threonine Phosphatase activity. Involved in regulation of double-strand break repair via homologous recombination. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PPP4C Products(5)

mRNA	Protein	Name
NM_001303503.2	NP_001290432.1	serine/threonine-protein phosphatase 4 catalytic subunit isoform 1
NM_001303504.2	NP_001290433.1	serine/threonine-protein phosphatase 4 catalytic subunit isoform 2
NM_001303506.2	NP_001290435.1	serine/threonine-protein phosphatase 4 catalytic subunit isoform 3
NM_001303507.2	NP_001290436.1	serine/threonine-protein phosphatase 4 catalytic subunit isoform 3
NM_002720.3	NP_002711.1	serine/threonine-protein phosphatase 4 catalytic subunit isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9647778	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	18715871	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of double-strand break repair	IMP IMP: Inferred from mutant phenotype	18614045	GOA
involved in regulation of double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	20154705	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	18614045	GOA
part of protein phosphatase 4 complex	IPI IPI: Inferred from physical interaction	18614045	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP4C Protein Structure

Metallophos

0
100
200
307 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 4 catalytic subunit

epididymis secretory sperm binding protein

PPP4C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP4C	P60510	PPP4R2	Homo sapiens	Q9NY27	Anti Tag CoIP	16085932
Intra	PPP4C	P60510	PPP4R2	Homo sapiens	Q9NY27	Anti Tag CoIP	19156129
Intra	PPP4C	P60510	PPP4R2	Homo sapiens	Q9NY27	Anti Tag CoIP	18715871
Intra	PPP4C	P60510	PPP4R2	Homo sapiens	Q9NY27	TAP	16085932
Intra	PPP4C	P60510	PPP4R2	Homo sapiens	Q9NY27	Anti Bait CoIP	17353931
Intra	PPP4C	P60510	PPP4R2	Homo sapiens	Q9NY27	Anti Tag CoIP	33961781
Intra	PPP4C	P60510	PPP4R2	Homo sapiens	Q9NY27	Anti Tag CoIP	27880917
Intra	PPP4C	P60510	TIPRL	Homo sapiens	O75663	Anti Tag CoIP	17384681
Intra	PPP4C	P60510	TIPRL	Homo sapiens	O75663	Anti Tag CoIP	27880917
Intra	PPP4C	P60510	TIPRL	Homo sapiens	O75663	Anti Tag CoIP	16085932
Intra	PPP4C	P60510	TIPRL	Homo sapiens	O75663	Anti Bait CoIP	17353931
Intra	PPP4C	P60510	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	18715871
Intra	PPP4C	P60510	IGBP1	Homo sapiens	P78318	Y2H	9647778
Intra	PPP4C	P60510	IGBP1	Homo sapiens	P78318	Y2H Array	32296183
Intra	PPP4C	P60510	IGBP1	Homo sapiens	P78318	TAP	16085932
Intra	PPP4C	P60510	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	33961781
Intra	PPP4C	P60510	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	19156129
Intra	PPP4C	P60510	IGBP1	Homo sapiens	P78318	Y2H Prey Pooling	32296183
Intra	PPP4C	P60510	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	27880917
Intra	PPP4C	P60510	IGBP1	Homo sapiens	P78318	Anti Bait CoIP	18614045
Intra	PPP4C	P60510	IGBP1	Homo sapiens	P78318	Validated Y2H	32296183
Intra	PPP4C	P60510	PPP4R1	Homo sapiens	Q8TF05	Anti Tag CoIP	27880917
Intra	PPP4C	P60510	PPP4R1	Homo sapiens	Q8TF05	Anti Tag CoIP	18715871
Intra	PPP4C	P60510	PPP4R1	Homo sapiens	Q8TF05	TAP	16085932
Intra	PPP4C	P60510	PPP4R1	Homo sapiens	Q8TF05	Anti Tag CoIP	33961781
Intra	PPP4C	P60510	PPP4R1	Homo sapiens	Q8TF05	Anti Bait CoIP	17353931
Intra	PPP4C	P60510	PTPA	Homo sapiens	Q15257	Anti Tag CoIP	33961781
Intra	PPP4C	P60510	PPP4R4	Homo sapiens	Q6NUP7	Anti Tag CoIP	27880917
Intra	PPP4C	P60510	PPP4R4	Homo sapiens	Q6NUP7	Anti Tag CoIP	18715871
Intra	PPP4C	P60510	PPP4R4	Homo sapiens	Q6NUP7	Anti Tag CoIP	33961781
Intra	PPP4C	P60510	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	33961781
Intra	PPP4C	P60510	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	19156129
Intra	PPP4C	P60510	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	27880917
Intra	PPP4C	P60510	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	18715871
Intra	PPP4C	P60510	PPP2R1A	Homo sapiens	P30153	Anti Bait CoIP	17353931
Intra	PPP4C	P60510	HDAC3	Homo sapiens	O15379	Anti Tag CoIP	15805470
Intra	PPP4C	P60510	HDAC3	Homo sapiens	O15379	Pull Down	15805470

Cross: Cross-species interaction Intra: Intraspecies interaction

PPP4C Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80873	PPP4C Antibody (YA687)	WB, IHC-F, IHC-P, ICC/IF	Human

Related Diseases

Diseases

Alias

Contagious Pustular Dermatitis

Ecthyma, Contagious	Orf
Ecthyma Contagiosum	Scabby Mouth
Sheep Pox	Thistle Disease
Contagious Pustular Dermatosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11028	PPP4C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PPP4C	VGNC	VGNC:69022
Mus musculus	PPP4C	MGD	MGI:1891763
Bos taurus	PPP4C	VGNC	VGNC:33268
Macaca mulatta	PPP4C	VGNC	VGNC:76384
Rattus norvegicus	PPP4C	RGD	RGD:621225
Canis familiaris	PPP4C	VGNC	VGNC:44921

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