Gentisein (Synonyms: NSC 329491; 1,3,7-Trihydroxyxanthone)

Cat. No.: HY-118166 Purity: 98.13%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Gentisein (NSC 329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC₅₀ value of 4.7 µM.

For research use only. We do not sell to patients.

Gentisein Chemical Structure

CAS No. : 529-49-7

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 225	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Gentisein (NSC 329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC₅₀ value of 4.7 µM^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	146.35 μM Compound: 3	Cytotoxicity against Taxol-resistant human A549 cells measured after 48 hrs by MTT assay Cytotoxicity against Taxol-resistant human A549 cells measured after 48 hrs by MTT assay	[PMID: 28065566]
COLO 320	IC₅₀	> 200 μM Compound: 45378	Antiproliferative activity against human COLO320 cells after 48 hrs by CCK8 assay Antiproliferative activity against human COLO320 cells after 48 hrs by CCK8 assay	[PMID: 28376372]
HeLa S3	IC₅₀	> 10 μM Compound: 20	Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
HepG2	IC₅₀	> 10 μM Compound: 20	Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
HepG2	IC₅₀	> 100 μM Compound: 1f	Cytotoxicity against human HepG2 cells assessed as NADH level after overnight incubation by MTS assay Cytotoxicity against human HepG2 cells assessed as NADH level after overnight incubation by MTS assay	[PMID: 22537683]
HepG2	IC₅₀	> 200 μM Compound: 45378	Antiproliferative activity against human HepG2 cells after 48 hrs by CCK8 assay Antiproliferative activity against human HepG2 cells after 48 hrs by CCK8 assay	[PMID: 28376372]
HepG2	IC₅₀	> 200 μM Compound: 2c	Growth inhibition of human HepG2 cells after 24 hrs by MTT assay Growth inhibition of human HepG2 cells after 24 hrs by MTT assay	[PMID: 29609121]
HepG2	IC₅₀	18.3 μM Compound: Table S1, R266C2	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 30684866]
HT-29	IC₅₀	> 10 μM Compound: 20	Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
Jurkat	IC₅₀	> 100 μM Compound: 1f	Cytotoxicity against human Jurkat T cells assessed as NADH level after overnight incubation by MTS assay Cytotoxicity against human Jurkat T cells assessed as NADH level after overnight incubation by MTS assay	[PMID: 22537683]
K562	IC₅₀	105.6 μM Compound: 45378	Antiproliferative activity against human K562 cells after 48 hrs by CCK8 assay Antiproliferative activity against human K562 cells after 48 hrs by CCK8 assay	[PMID: 28376372]
KB	IC₅₀	> 10 μM Compound: 20	Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
MCF7	IC₅₀	> 10 μM Compound: 20	Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
MCF7	IC₅₀	> 200 μM Compound: 2c	Growth inhibition of human MCF7 cells after 24 hrs by MTT assay Growth inhibition of human MCF7 cells after 24 hrs by MTT assay	[PMID: 29609121]
MCF7	IC₅₀	31.2 μM Compound: 45378	Antiproliferative activity against human MCF7 cells after 48 hrs by CCK8 assay Antiproliferative activity against human MCF7 cells after 48 hrs by CCK8 assay	[PMID: 28376372]
MDA-MB-231	IC₅₀	> 200 μM Compound: 2c	Growth inhibition of human MDA-MB-231 cells after 24 hrs by MTT assay Growth inhibition of human MDA-MB-231 cells after 24 hrs by MTT assay	[PMID: 29609121]
MDA-MB-231	IC₅₀	25.1 μM Compound: 45378	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by CCK8 assay	[PMID: 28376372]
NCI/ADR-RES	IC₅₀	192.66 μM Compound: 3	Cytotoxicity against human MCF7/ADR cells measured after 48 hrs by MTT assay Cytotoxicity against human MCF7/ADR cells measured after 48 hrs by MTT assay	[PMID: 28065566]
SMMC-7721	IC₅₀	38.52 μM Compound: 3	Cytotoxicity against Taxol-resistant human SMMC7721 cells measured after 48 hrs by MTT assay Cytotoxicity against Taxol-resistant human SMMC7721 cells measured after 48 hrs by MTT assay	[PMID: 28065566]

Molecular Weight

244.20

Formula

C₁₃H₈O₅

CAS No.

529-49-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=C(C=C(C=C2O)O)OC3=C1C=C(C=C3)O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (409.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0950 mL	20.4750 mL	40.9500 mL
5 mM	0.8190 mL	4.0950 mL	8.1900 mL
10 mM	0.4095 mL	2.0475 mL	4.0950 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.13%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (247 KB) HNMR (252 KB) LCMS (259 KB)

Handling Instructions (2659 KB)

References

[1]. Wang H, et al. Identification and determination of four metabolites of mangiferin in rat urine. J Pharm Biomed Anal. 2007;45(5):793-798. [Content Brief]

[2]. Tzankova, Virginia et al. (2010). Inhibition of 5-HT uptake by some constituents of Hypericum annulatum in rat brain in vitro. Pharmacologyonline. 2.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.0950 mL	20.4750 mL	40.9500 mL	102.3751 mL
	5 mM	0.8190 mL	4.0950 mL	8.1900 mL	20.4750 mL
	10 mM	0.4095 mL	2.0475 mL	4.0950 mL	10.2375 mL
	15 mM	0.2730 mL	1.3650 mL	2.7300 mL	6.8250 mL
	20 mM	0.2048 mL	1.0238 mL	2.0475 mL	5.1188 mL
	25 mM	0.1638 mL	0.8190 mL	1.6380 mL	4.0950 mL
	30 mM	0.1365 mL	0.6825 mL	1.3650 mL	3.4125 mL
	40 mM	0.1024 mL	0.5119 mL	1.0238 mL	2.5594 mL
	50 mM	0.0819 mL	0.4095 mL	0.8190 mL	2.0475 mL
	60 mM	0.0683 mL	0.3413 mL	0.6825 mL	1.7063 mL
	80 mM	0.0512 mL	0.2559 mL	0.5119 mL	1.2797 mL
	100 mM	0.0410 mL	0.2048 mL	0.4095 mL	1.0238 mL

Gentisein Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gentisein529-49-7NSC 329491 1,3,7-TrihydroxyxanthoneNSC329491NSC-3294915-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorserotonin uptakemetaboliteantidepressantInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Gentisein (Synonyms: NSC 329491; 1,3,7-Trihydroxyxanthone)

Customer Review

Gentisein Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All 5-HT Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Gentisein Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report