2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Glisoxepide

Glisoxepide, a sulphonamide derivative, is an orally available nonselective K(ATP) channel blocker, with antihyperglycemic activity and cardiovascular regulation effect.

For research use only. We do not sell to patients.

Glisoxepide Chemical Structure

Glisoxepide Chemical Structure

CAS No. : 25046-79-1

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10 mg USD 685 In-stock
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Based on 1 publication(s) in Google Scholar

Glisoxepide Related Antibodies

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Description

Glisoxepide, a sulphonamide derivative, is an orally available nonselective K(ATP) channel blocker, with antihyperglycemic activity and cardiovascular regulation effect[1][2][3].

IC50 & Target

K(ATP) channel[1]
In Vitro

Glisoxepide inhibits the uptake of bile acids into isolated rat hepatocytes[3].
Glisoxepide noncompetitively inhibits the cholate uptake with a Ki of 200 μM[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glisoxepide Related Antibodies
Molecular Weight

449.52

Formula

C20H27N5O5S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=NOC(C)=C1)NCCC2=CC=C(S(=O)(NC(NN3CCCCCC3)=O)=O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4.5 mg/mL (10.01 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2246 mL 11.1230 mL 22.2460 mL
5 mM 0.4449 mL 2.2246 mL 4.4492 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2246 mL 11.1230 mL 22.2460 mL 55.6149 mL
5 mM 0.4449 mL 2.2246 mL 4.4492 mL 11.1230 mL
10 mM 0.2225 mL 1.1123 mL 2.2246 mL 5.5615 mL
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Glisoxepide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glisoxepide25046-79-1Potassium ChannelKcsAsulphonamidesulfonylureasK(ATP)potassiumchannelantihyperglycemicsulphonylureacardiovascularregulationInhibitorinhibitorinhibit

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