2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. [Glp5,(Me)Phe8,Sar9] Substance P (5-11)

[Glp5,(Me)Phe8,Sar9] Substance P (5-11)  (Synonyms: DiMe-C7)

Cat. No.: HY-P3801 Purity: 99.01%
COA Handling Instructions

Molarity Calculator

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) Chemical Structure

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) Chemical Structure

CAS No. : 77128-69-9

Size Price Stock Quantity
1 mg USD 50 In-stock
5 mg USD 120 In-stock
10 mg USD 180 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) Related Antibodies

Top Publications Citing Use of Products

View All Neurokinin Receptor Isoform Specific Products:

View All Isoforms
NK1 NK2 NK3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats[1][2][3].

In Vivo

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (2 μg/side; inject into the ventral tegmental area; single) exhibits selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain[1].
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (0.5, 1.5, 3 μg/side; inject into the ventral tegmental area; single) increases motor activity and induces recovery of addictive agent-seeking behavior in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (300-350 g)[1].
Dosage: 2 µg/side
Administration: Inject into the ventral tegmental area; single
Result: Selectively activated mesolimbic and mesocortical dopamine metabolism.
Animal Model: Male Wistar rats (300-350 g)[2].
Dosage: 0.5, 1.5, 3 µg/side
Administration: Inject into the ventral tegmental area; single
Result: Significantly increased locomotor activity when at 3 µg/side.
Molecular Weight

880.06

Formula

C43H61N9O9S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

pGlu-Gln-Phe-N-Methyl-Phe-Sar-Leu-Met-NH2
Sequence Shortening

pGlp-QF(-Me)F-Sar-LM-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (113.63 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1363 mL 5.6814 mL 11.3629 mL
5 mM 0.2273 mL 1.1363 mL 2.2726 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1363 mL 5.6814 mL 11.3629 mL 28.4072 mL
5 mM 0.2273 mL 1.1363 mL 2.2726 mL 5.6814 mL
10 mM 0.1136 mL 0.5681 mL 1.1363 mL 2.8407 mL
15 mM 0.0758 mL 0.3788 mL 0.7575 mL 1.8938 mL
20 mM 0.0568 mL 0.2841 mL 0.5681 mL 1.4204 mL
25 mM 0.0455 mL 0.2273 mL 0.4545 mL 1.1363 mL
30 mM 0.0379 mL 0.1894 mL 0.3788 mL 0.9469 mL
40 mM 0.0284 mL 0.1420 mL 0.2841 mL 0.7102 mL
50 mM 0.0227 mL 0.1136 mL 0.2273 mL 0.5681 mL
60 mM 0.0189 mL 0.0947 mL 0.1894 mL 0.4735 mL
80 mM 0.0142 mL 0.0710 mL 0.1420 mL 0.3551 mL
100 mM 0.0114 mL 0.0568 mL 0.1136 mL 0.2841 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Glp5,(Me)Phe8,Sar9] Substance P (5-11)77128-69-9DiMe-C7Neurokinin ReceptorNK receptorTachykinin receptorseeking behaviordopamineneuropeptideNK1RInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
[Glp5,(Me)Phe8,Sar9] Substance P (5-11)
Cat. No.:
HY-P3801
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.