Glu-urea-Glu-NHS ester

Name: Glu-urea-Glu-NHS ester
Brand: MedChemExpress
SKU: HY-147287
Rating: 4.5 (1 reviews)

Cat. No.: HY-147287 Purity: 97.45%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Glu-urea-Glu-NHS ester (compound 21) is an activated N-hydroxysuccinamide (NHS) ester of Glu-urea-Glu which can be used as a pharmacophore for linking with prostate specific membrane antigen (PSMA) inhibitors.

For research use only. We do not sell to patients.

Glu-urea-Glu-NHS ester Chemical Structure

CAS No. : 1228927-36-3

Size	Price	Stock	Quantity
5 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 610	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Molecular Weight

585.64

Formula

C₂₇H₄₃N₃O₁₁

CAS No.

1228927-36-3

Appearance

Solid

Color

White to off-white

SMILES

CC(C)(C)OC(CC[C@@H](C(OC(C)(C)C)=O)NC(N[C@H](C(OC(C)(C)C)=O)CCC(ON1C(CCC1=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (170.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7075 mL	8.5377 mL	17.0753 mL
5 mM	0.3415 mL	1.7075 mL	3.4151 mL
10 mM	0.1708 mL	0.8538 mL	1.7075 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 97.45%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (249 KB) HNMR (270 KB) RP-HPLC (241 KB) MS (67 KB)

Handling Instructions (2659 KB)

References

[1]. Lu G, et al. Synthesis and SAR of ⁹⁹mTc/Re-labeled small molecule prostate specific membrane antigen inhibitors with novel polar chelates. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1557-63. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7075 mL	8.5377 mL	17.0753 mL	42.6883 mL
	5 mM	0.3415 mL	1.7075 mL	3.4151 mL	8.5377 mL
	10 mM	0.1708 mL	0.8538 mL	1.7075 mL	4.2688 mL
	15 mM	0.1138 mL	0.5692 mL	1.1384 mL	2.8459 mL
	20 mM	0.0854 mL	0.4269 mL	0.8538 mL	2.1344 mL
	25 mM	0.0683 mL	0.3415 mL	0.6830 mL	1.7075 mL
	30 mM	0.0569 mL	0.2846 mL	0.5692 mL	1.4229 mL
	40 mM	0.0427 mL	0.2134 mL	0.4269 mL	1.0672 mL
	50 mM	0.0342 mL	0.1708 mL	0.3415 mL	0.8538 mL
	60 mM	0.0285 mL	0.1423 mL	0.2846 mL	0.7115 mL
	80 mM	0.0213 mL	0.1067 mL	0.2134 mL	0.5336 mL
	100 mM	0.0171 mL	0.0854 mL	0.1708 mL	0.4269 mL