Glutor 

Glutor is a selective GLUT 1/2/3 inhibitor that can suppress glucose uptake. Glutor can inhibit glycolysis and has anti-tumor activity, inducing cell apoptosis^[1][2].

Glutor reduced the uptake of 2-DG with similar efficacy in different cancer cell lines, such as HCT116 (IC₅₀ = 10.8 nM), UM-UC-3 (IC₅₀ = 8.3 nM), UO-31 (IC₅₀ = 3.6 nM), and MIA PaCa-2 (IC₅₀ = 1.1 nM)^[1].
Glutor effectively decreases glycolysis in HCT116 cells, thereby preventing the reduction of oxidative phosphorylation rates after glucose addition^[1].
Glutor inhibits the proliferation of malignant cell lines without harming the growth of non-malignant peripheral blood mononuclear cells (PBMCs) and IMR-90 embryonic lung cells^[1].
Glutor (0.5μM, 24-48h) suppresses the glucose uptake-induced upregulation of GLUT-1 and GLUT-3 expression^[1].
Glutor (0.0001-1μM, 24h) inhibits the number of DL cells in a time- and dose-dependent manner, with an Glutor reduced the uptake of 2-DG with similar efficacy in different cancer cell lines, such as HCT116 (IC₅₀ = 10.8 nM), UM-UC-3 (IC₅₀ = 8.3 nM), UO-31 (IC₅₀ = 3.6 nM), and MIA PaCa-2 (IC₅₀ = 1.1 nM)^[1].
Glutor effectively decreases glycolysis in HCT116 cells, thereby preventing the reduction of oxidative phosphorylation rates after glucose addition^[1].
Glutor inhibits the proliferation of malignant cell lines without harming the growth of non-malignant peripheral blood mononuclear cells (PBMCs) and IMR-90 embryonic lung cells^[1].
Glutor (0.5 μM, 24-48 h) suppresses the glucose uptake-induced upregulation of GLUT-1 and GLUT-3 expression^[1].
Glutor (0.0001-1 μM, 24 h) inhibits the number of DL cells in a time- and dose-dependent manner, with an IC50 of 0.01 μM, showing no cytotoxicity to thymocytes^[2].
Glutor (0.01-1 μM, 24 h) induces apoptosis in DL cells^[2].
Glutor (0.01-1 μM, 24 h) links tumor inhibition to the regulation of cell survival and metabolic regulatory molecules^[2].
Glutor (0.01-1 μM, 2 h) increases the expression of reactive oxygen species (ROS) in DL cells^[2].
Glutor (0.01-1 μM, 24 h) triggers depolarization of the mitochondrial membrane, disrupting the pH homeostasis of DL cells and altering their chemical sensitivity^[2].
of 0.01 μM, showing no cytotoxicity to thymocytes^[2].
Glutor (0.01-1 μM, 24 h) induces apoptosis in DL cells^[2].
Glutor (0.01-1 μM, 24 h) links tumor inhibition to the regulation of cell survival and metabolic regulatory molecules^[2].
Glutor (0.01-1 μM, 2 h) increases the expression of reactive oxygen species (ROS) in DL cells^[2].
Glutor (0.01-1 μM, 24 h) triggers depolarization of the mitochondrial membrane, disrupting the pH homeostasis of DL cells and altering their chemical sensitivity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

536.62

C₃₁H₃₂N₆O₃

2561471-22-3

Solid

White to off-white

O=C([C@@]1(C)N(C(C2=CC(C3=CC=CC=C3)=NN2C1)=O)CC(C=C4)=CC=C4N5CCOCC5)NCC6=CC=CN=C6

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Reckzeh ES, et al. Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth. Cell Chem Biol. 2019;26(9):1214-1228.e25.  [Content Brief]

  [2]. Mithlesh Kumar Temre， et al. Glutor, a Glucose Transporter Inhibitor, Exerts Antineoplastic Action on Tumor Cells of Thymic Origin: Implication of Modulated Metabolism, Survival, Oxidative Stress, Mitochondrial Membrane Potential, pH Homeostasis, and Chemosensitivity. Front Oncol. 2022 Jun 30:12:925666.  [Content Brief]