Gly-Gly-Gly-PEG4-DBCO

Name: Gly-Gly-Gly-PEG4-DBCO
Brand: MedChemExpress
SKU: HY-140309
Rating: 4.5 (1 reviews)

Cat. No.: HY-140309 Purity: 98.35%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Gly-Gly-Gly-PEG4-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Gly-Gly-Gly-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Gly-Gly-Gly-PEG4-DBCO Chemical Structure

CAS No. : 2353409-80-8

Size	Price	Stock	Quantity
5 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 340	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

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View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
References
Customer Review

Description

Gly-Gly-Gly-PEG4-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. Gly-Gly-Gly-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC₅₀ & Target

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

694.77

Formula

C₃₅H₄₆N₆O₉

CAS No.

2353409-80-8

Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCOCCOCCOCCOCCNC(CNC(CNC(CN)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (143.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Methanol : 50 mg/mL (71.97 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4393 mL	7.1966 mL	14.3933 mL
5 mM	0.2879 mL	1.4393 mL	2.8787 mL
10 mM	0.1439 mL	0.7197 mL	1.4393 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.35%

Select Batch:

Data Sheet (267 KB) SDS (252 KB)

COA (242 KB) HNMR (258 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Methanol / DMSO	1 mM	1.4393 mL	7.1966 mL	14.3933 mL	35.9831 mL
	5 mM	0.2879 mL	1.4393 mL	2.8787 mL	7.1966 mL
	10 mM	0.1439 mL	0.7197 mL	1.4393 mL	3.5983 mL
	15 mM	0.0960 mL	0.4798 mL	0.9596 mL	2.3989 mL
	20 mM	0.0720 mL	0.3598 mL	0.7197 mL	1.7992 mL
	25 mM	0.0576 mL	0.2879 mL	0.5757 mL	1.4393 mL
	30 mM	0.0480 mL	0.2399 mL	0.4798 mL	1.1994 mL
	40 mM	0.0360 mL	0.1799 mL	0.3598 mL	0.8996 mL
	50 mM	0.0288 mL	0.1439 mL	0.2879 mL	0.7197 mL
	60 mM	0.0240 mL	0.1199 mL	0.2399 mL	0.5997 mL
DMSO	80 mM	0.0180 mL	0.0900 mL	0.1799 mL	0.4498 mL
DMSO	100 mM	0.0144 mL	0.0720 mL	0.1439 mL	0.3598 mL