Gly-Pro-pNA hydrochloride

Name: Gly-Pro-pNA hydrochloride
Brand: MedChemExpress
SKU: HY-119244
Rating: 4.5 (1 reviews)

Cat. No.: HY-119244 Purity: 99.92%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Gly-Pro-pNA hydrochloride is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV). Gly-Pro-pNA can be used to screen for DPP IV inhibitors.

For research use only. We do not sell to patients.

Gly-Pro-pNA hydrochloride Chemical Structure

CAS No. : 103213-34-9

Size	Price	Stock	Quantity
5 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 65	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Gly-Pro-pNA hydrochloride is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV). Gly-Pro-pNA can be used to screen for DPP IV inhibitors^[1].

Molecular Weight

328.75

Formula

C₁₃H₁₇ClN₄O₄

CAS No.

103213-34-9

Appearance

Solid

Color

White to yellow

SMILES

O=C(N1CCC[C@H]1C(NC2=CC=C(C=C2)[N+]([O-])=O)=O)CN.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (304.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (152.09 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0418 mL	15.2091 mL	30.4182 mL
5 mM	0.6084 mL	3.0418 mL	6.0837 mL
10 mM	0.3042 mL	1.5209 mL	3.0418 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (253 KB) HNMR (264 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

References

[1]. Kim YB, et al. Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118). Arch Biochem Biophys. 2006;445(1):9-18. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.0418 mL	15.2091 mL	30.4183 mL	76.0456 mL
	5 mM	0.6084 mL	3.0418 mL	6.0837 mL	15.2091 mL
	10 mM	0.3042 mL	1.5209 mL	3.0418 mL	7.6046 mL
	15 mM	0.2028 mL	1.0139 mL	2.0279 mL	5.0697 mL
	20 mM	0.1521 mL	0.7605 mL	1.5209 mL	3.8023 mL
	25 mM	0.1217 mL	0.6084 mL	1.2167 mL	3.0418 mL
	30 mM	0.1014 mL	0.5070 mL	1.0139 mL	2.5349 mL
	40 mM	0.0760 mL	0.3802 mL	0.7605 mL	1.9011 mL
	50 mM	0.0608 mL	0.3042 mL	0.6084 mL	1.5209 mL
	60 mM	0.0507 mL	0.2535 mL	0.5070 mL	1.2674 mL
	80 mM	0.0380 mL	0.1901 mL	0.3802 mL	0.9506 mL
	100 mM	0.0304 mL	0.1521 mL	0.3042 mL	0.7605 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.