2. Metabolic Enzyme/Protease
  3. Dipeptidyl Peptidase
  4. Gly-Pro-pNA hydrochloride

Gly-Pro-pNA hydrochloride is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV). Gly-Pro-pNA can be used to screen for DPP IV inhibitors.

For research use only. We do not sell to patients.

Gly-Pro-pNA hydrochloride Chemical Structure

Gly-Pro-pNA hydrochloride Chemical Structure

CAS No. : 103213-34-9

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5 mg USD 40 In-stock
10 mg USD 65 In-stock
25 mg USD 130 In-stock
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Based on 1 publication(s) in Google Scholar

Gly-Pro-pNA hydrochloride Related Antibodies

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Description

Gly-Pro-pNA hydrochloride is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV). Gly-Pro-pNA can be used to screen for DPP IV inhibitors[1].

Molecular Weight

328.75

Formula

C13H17ClN4O4
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(N1CCC[C@H]1C(NC2=CC=C(C=C2)[N+]([O-])=O)=O)CN.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (304.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (152.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0418 mL 15.2091 mL 30.4182 mL
5 mM 0.6084 mL 3.0418 mL 6.0837 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.92%

COA (253 KB) HNMR (264 KB) LCMS (91 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.0418 mL 15.2091 mL 30.4183 mL 76.0456 mL
5 mM 0.6084 mL 3.0418 mL 6.0837 mL 15.2091 mL
10 mM 0.3042 mL 1.5209 mL 3.0418 mL 7.6046 mL
15 mM 0.2028 mL 1.0139 mL 2.0279 mL 5.0697 mL
20 mM 0.1521 mL 0.7605 mL 1.5209 mL 3.8023 mL
25 mM 0.1217 mL 0.6084 mL 1.2167 mL 3.0418 mL
30 mM 0.1014 mL 0.5070 mL 1.0139 mL 2.5349 mL
40 mM 0.0760 mL 0.3802 mL 0.7605 mL 1.9011 mL
50 mM 0.0608 mL 0.3042 mL 0.6084 mL 1.5209 mL
60 mM 0.0507 mL 0.2535 mL 0.5070 mL 1.2674 mL
80 mM 0.0380 mL 0.1901 mL 0.3802 mL 0.9506 mL
100 mM 0.0304 mL 0.1521 mL 0.3042 mL 0.7605 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Gly-Pro-pNA hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gly-Pro-pNA103213-34-9Dipeptidyl PeptidaseDPPSubstrateDPP IVInhibitorinhibitorinhibit

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