2. Others Metabolic Enzyme/Protease Apoptosis
  3. Isotope-Labeled Compounds Endogenous Metabolite Apoptosis
  4. Glycochenodeoxycholic acid-d4

Glycochenodeoxycholic acid-d4  (Synonyms: Chenodeoxycholylglycine-d4)

Cat. No.: HY-N2334S Purity: 98.00%
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Glycochenodeoxycholic acid-d4 is the deuterium labeled Glycochenodeoxycholic acid. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) induces hepatocyte apoptosis[1][2].

For research use only. We do not sell to patients.

Glycochenodeoxycholic acid-d<sub>4</sub> Chemical Structure

Glycochenodeoxycholic acid-d4 Chemical Structure

CAS No. : 1201918-16-2

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Based on 1 publication(s) in Google Scholar

Other Forms of Glycochenodeoxycholic acid-d4:

Glycochenodeoxycholic acid-d4 Related Antibodies

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Description

Glycochenodeoxycholic acid-d4 is the deuterium labeled Glycochenodeoxycholic acid. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) induces hepatocyte apoptosis[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glycochenodeoxycholic acid-d4 Related Antibodies
Molecular Weight

453.65

Formula

C26H39D4NO5
CAS No.
Unlabeled CAS

640-79-9
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCC(O)=O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C([2H])([2H])[C@@H](C([2H])([2H])C4)O)([H])C[C@H]3O)C
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (220.43 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2043 mL 11.0217 mL 22.0434 mL
5 mM 0.4409 mL 2.2043 mL 4.4087 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2043 mL 11.0217 mL 22.0434 mL 55.1086 mL
5 mM 0.4409 mL 2.2043 mL 4.4087 mL 11.0217 mL
10 mM 0.2204 mL 1.1022 mL 2.2043 mL 5.5109 mL
15 mM 0.1470 mL 0.7348 mL 1.4696 mL 3.6739 mL
20 mM 0.1102 mL 0.5511 mL 1.1022 mL 2.7554 mL
25 mM 0.0882 mL 0.4409 mL 0.8817 mL 2.2043 mL
30 mM 0.0735 mL 0.3674 mL 0.7348 mL 1.8370 mL
40 mM 0.0551 mL 0.2755 mL 0.5511 mL 1.3777 mL
50 mM 0.0441 mL 0.2204 mL 0.4409 mL 1.1022 mL
60 mM 0.0367 mL 0.1837 mL 0.3674 mL 0.9185 mL
80 mM 0.0276 mL 0.1378 mL 0.2755 mL 0.6889 mL
100 mM 0.0220 mL 0.1102 mL 0.2204 mL 0.5511 mL
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Glycochenodeoxycholic acid-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycochenodeoxycholic acid-d41201918-16-2Chenodeoxycholylglycine-d4Isotope-Labeled CompoundsEndogenous MetaboliteApoptosisInhibitorinhibitorinhibit

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