2. Isotope-Labeled Compounds
  3. Isotope-Labeled Bile Acids

Isotope-Labeled Bile Acids

Bile Acids ( BAs ) are the main organic component of bile, which is the general name of several similar steroid acids. BAs are generally classified into primary bile acids and secondary bile acids according to the source. They can also be divided into free bile acids and conjugated bile acids according to the chemical structure. MedChemExpress ( MCE ) offers a wide variety of Stable Isotope-Labeled Bile Acids that can be used as internal standards for the quantitative GC/LC-MS analysis and involved the study of bile acid synthesis, transport, and metabolism etc.

Isotope-Labeled Bile Acids (60):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0324S
    Cholic acid-d4 116380-66-6 99.86%
    Cholic acid-d4 is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
    Cholic acid-d<sub>4</sub>
  • HY-B1788S
    Taurocholic acid-d4 sodium 2410279-93-3 99.29%
    Taurocholic acid-d4 (sodium) is the deuterium labeled Taurocholic acid. Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.
    Taurocholic acid-d<sub>4</sub> sodium
  • HY-76847S
    Chenodeoxycholic Acid-d4 99102-69-9 99.19%
    Chenodeoxycholic Acid-d4 is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
    Chenodeoxycholic Acid-d<sub>4</sub>
  • HY-N0593S
    Deoxycholic acid-d4 112076-61-6 98.0%
    Deoxycholic acid-d4 is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
    Deoxycholic acid-d<sub>4</sub>
  • HY-B0172S
    Lithocholic acid-d4 83701-16-0 99.72%
    Lithocholic acid-d4 is the deuterium labeled Lithocholic acid, which is a toxic secondary bile acid[1].
    Lithocholic acid-d<sub>4</sub>
  • HY-13771S1
    Ursodeoxycholic acid-13C 63296-46-8
    Ursodeoxycholic acid-13C is the 13C labeled Ursodeoxycholic acid. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active[1][2].
    Ursodeoxycholic acid-<sup>13</sup>C
  • HY-N0324S2
    Cholic acid-13C 52886-36-9 ≥98.0%
    Cholic acid-13C is the 13C-labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
    Cholic acid-<sup>13</sup>C
  • HY-N0324S1
    Cholic acid-d5 53007-09-3 ≥98.0%
    Cholic acid-d5 is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
    Cholic acid-d<sub>5</sub>
  • HY-N1423S
    Glycocholic acid-d4 1201918-15-1 99.38%
    Glycocholic acid-d4 is the deuterium labeled Glycocholic acid. Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1].
    Glycocholic acid-d<sub>4</sub>
  • HY-N0593S3
    Deoxycholic acid-13C 52886-37-0 98.00%
    Deoxycholic acid-13C is the 13C-labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
    Deoxycholic acid-<sup>13</sup>C
  • HY-N1429S1
    Taurochenodeoxycholic acid-d5 sodium 98.12%
    Taurochenodeoxycholic acid-d5 (sodium) is the deuterium labeled Taurochenodeoxycholic acid sodium. Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].
    Taurochenodeoxycholic acid-d<sub>5</sub> sodium
  • HY-N2334S
    Glycochenodeoxycholic acid-d4 1201918-16-2 98.00%
    Glycochenodeoxycholic acid-d4 is the deuterium labeled Glycochenodeoxycholic acid. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) induces hepatocyte apoptosis[1][2].
    Glycochenodeoxycholic acid-d<sub>4</sub>
  • HY-113478S
    Ursodeoxycholic acid-2,2,4,4-d4 347841-46-7 99.52%
    Ursodeoxycholic acid-2,2,4,4-d4 is the deuterium labeled Ursodeoxycholic acid (HY-13771). Ursodeoxycholic acid is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection[1][2][3][4][5].
    Ursodeoxycholic acid-2,2,4,4-d<sub>4</sub>
  • HY-N1424S
    Glycoursodeoxycholic Acid-d4 2044276-17-5 98.88%
    Glycoursodeoxycholic acid-d4 (Ursodeoxycholylglycine-d4) is the deuterium labeled Glycoursodeoxycholic acid. Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid[1][2].
    Glycoursodeoxycholic Acid-d<sub>4</sub>
  • HY-125731S1
    Glycodeoxycholic acid-d6 2483831-98-5 98.94%
    Glycodeoxycholic acid-d6 is the deuterium labeled Glycodeoxycholic Acid. Glycodeoxycholic Acid is an endogenous metabolite.
    Glycodeoxycholic acid-d<sub>6</sub>
  • HY-116374S
    Glycolithocholic acid-d4 2044276-16-4 98.38%
    Glycolithocholic acid-d4 is the deuterium labeled Glycolithocholic acid. Glycolithocholic acid, an endogenous metabolite, is a glycine-conjugated secondary bile acid and can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) [1][2][3][4].
    Glycolithocholic acid-d<sub>4</sub>
  • HY-B1788S1
    Taurocholic acid-d4 252030-90-3 99.50%
    Taurocholic acid-d4 is deuterium labeled Taurocholic acid. Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.
    Taurocholic acid-d<sub>4</sub>
  • HY-N1423S1
    Glycocholic acid-d5 2170091-95-7
    Glycocholic acid-d5 is the deuterium labeled Glycocholic acid. Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways.
    Glycocholic acid-d<sub>5</sub>
  • HY-125731S
    Glycodeoxycholic acid-d4 1069132-37-1 99.52%
    Glycodeoxycholic acid-d4 is the deuterium labeled Glycodeoxycholic Acid. Glycodeoxycholic Acid is an endogenous metabolite.
    Glycodeoxycholic acid-d<sub>4</sub>
  • HY-12222S1
    Obeticholic Acid-d4 ≥98.0%
    Obeticholic Acid-d4 is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].
    Obeticholic Acid-d<sub>4</sub>