Glycocholic acid-d₄

Name: Glycocholic acid-d 4
Brand: MedChemExpress
SKU: HY-N1423S
Rating: 4.5 (1 reviews)

Cat. No.: HY-N1423S Purity: 99.38%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Glycocholic acid-d₄ is the deuterium labeled Glycocholic acid. Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1].

For research use only. We do not sell to patients.

Glycocholic acid-d<sub>4</sub> Chemical Structure

Glycocholic acid-d₄ Chemical Structure

CAS No. : 1201918-15-1

Size	Price	Stock	Quantity
1 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Glycocholic acid-d₄:

Glycocholic acid In-stock

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

469.65

Formula

C₂₆H₃₉D₄NO₆

CAS No.

1201918-15-1

Unlabeled CAS

475-31-0

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@]([C@H](C)CCC(NCC(O)=O)=O)([H])CC3)([C@@H](O)C[C@]2([H])[C@]4(C)[C@](C([2H])([2H])[C@H](O)C([2H])([2H])C4)([H])C1)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (212.92 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1292 mL	10.6462 mL	21.2925 mL
5 mM	0.4258 mL	2.1292 mL	4.2585 mL
10 mM	0.2129 mL	1.0646 mL	2.1292 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.38%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (248 KB) HNMR (351 KB) RP-HPLC (548 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Lo YL, et al. Inhibit multidrug resistance and induce apoptosis by using glycocholic acid and epirubicin. Eur J Pharm Sci. 2008 Sep 2;35(1-2):52-67. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1292 mL	10.6462 mL	21.2925 mL	53.2311 mL
	5 mM	0.4258 mL	2.1292 mL	4.2585 mL	10.6462 mL
	10 mM	0.2129 mL	1.0646 mL	2.1292 mL	5.3231 mL
	15 mM	0.1419 mL	0.7097 mL	1.4195 mL	3.5487 mL
	20 mM	0.1065 mL	0.5323 mL	1.0646 mL	2.6616 mL
	25 mM	0.0852 mL	0.4258 mL	0.8517 mL	2.1292 mL
	30 mM	0.0710 mL	0.3549 mL	0.7097 mL	1.7744 mL
	40 mM	0.0532 mL	0.2662 mL	0.5323 mL	1.3308 mL
	50 mM	0.0426 mL	0.2129 mL	0.4258 mL	1.0646 mL
	60 mM	0.0355 mL	0.1774 mL	0.3549 mL	0.8872 mL
	80 mM	0.0266 mL	0.1331 mL	0.2662 mL	0.6654 mL
	100 mM	0.0213 mL	0.1065 mL	0.2129 mL	0.5323 mL