GMP Small molecules for Antibody-drug Conjugate(ADC)

ADC-related small molecules High purity Batch to batch consistency DMF Filing

GMP (Good Manufacturing Practice) is the fundamental principle for drug production and quality management. GMP ADC related small molecule products include ADC Payload, ADC Linker+Payload, and related intermediate. The GMP ADC related small molecule products provided by MCE strictly follow the cGMP guidelines for production, with reliable quality and high cost-effectiveness. MCE has successfully filed a series of products with the FDA, and this type of product has completed systematic and complete quality research work, supporting the declaration work and on-site audit from IND to NDA.

Products (24)
Background

Cat. No.	Product Name	CAS No.	Target

HY-13631AG

Exatecan (mesylate) (GMP)	169869-90-3	ADC Cytotoxin Topoisomerase
Exatecan mesylate (DX8951f ) GMP is a GMP-class Exatecan (HY-13631). Exatecan is a DNA topoisomerase I inhibitor, with an IC₅₀ of 2.2 μM (0.975 μg/mL), and can be used in cancer research.

HY-15575G

VcMMAE (GMP)	646502-53-6	Drug-Linker Conjugates for ADC
VcMMAE (MC-Val-Cit-PAB-MMAE) (GMP) is VcMMAE (HY-15575) produced by using GMP guidelines. VcMMAE is a drug-linker conjugate for ADC.

HY-15162G

Monomethyl auristatin E (GMP)	474645-27-7	Microtubule/Tubulin ADC Cytotoxin Apoptosis
Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor.

HY-15582G

Auristatin E (GMP)	160800-57-7	Microtubule/Tubulin ADC Cytotoxin
Auristatin E (GMP) is Auristatin E (HY-15582) produced by using GMP guidelines. Auristatin E is a tubulin polymerization inhibitor.

HY-78932G

Dap-NE hydrochloride (GMP)	2019182-02-4	Others
Dap-NE hydrochloride (GMP) is Dap-NE hydrochloride (HY-78932A) produced by using GMP guidelines. Dap-NE hydrochloride is an intermediate used in the synthesis of antibody-drug conjugates (ADCs).

HY-78931G

Boc-Dap-NE (GMP)	160800-65-7	ADC Linker
Boc-Dap-NE (GMP) is Boc-Dap-NE (HY-78931) produced by using GMP guidelines. Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.

HY-15578G

McMMAF (GMP)	863971-19-1	Drug-Linker Conjugates for ADC
McMMAF GMP is a GMP grade McMMAF (HY-15578). McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC). McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent.

HY-15579BG

MMAF sodium (GMP)	1799706-65-2	Microtubule/Tubulin ADC Cytotoxin
MMAF sodium GMP is a GMP grade MMAF (sodium) (HY-15579B). MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A.

HY-15579G

MMAF (GMP)	745017-94-1	Microtubule/Tubulin ADC Cytotoxin
MMAF (Monomethylauristatin F) GMP is a GMP grade MMAF (HY-15579). MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A.

HY-16700G

PNU-159682 (GMP)	202350-68-3	Topoisomerase ADC Cytotoxin
PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

HY-100374G

Val-Cit-PAB-MMAE (GMP)	644981-35-1	Drug-Linker Conjugates for ADC
Val-Cit-PAB-MMAE GMP is a GMP grade Val-Cit-PAB-MMAE (HY-100374). Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization.

HY-131833G

Fmoc-Gly-Gly-Phe-OH (GMP)	160036-44-2	ADC Linker
Fmoc-Gly-Gly-Phe-OH GMP is a GMP grade Fmoc-Gly-Gly-Phe-OH (HY-131833). Fmoc-Gly-Gly-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-12362G

Val-cit-PAB-OH (GMP)	159857-79-1	ADC Linker
Val-cit-PAB-OH GMP is a GMP grade Val-cit-PAB-OH (HY-12362). Val-cit-PAB-OH is a degradable ADC linker.

HY-15794G

Nemorubicin (GMP)	108852-90-0	G-quadruplex
Nemorubicin (Methoxymorpholinyl doxorubicin) GMP is a GMP-class Nemorubicin (HY-15794). Nemorubicin is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity.

HY-19318G

Fmoc-Val-Cit-PAB (GMP)	159858-22-7	ADC Linker
Fmoc-Val-Cit-PAB GMP is a GMP grade Fmoc-Val-Cit-PAB (HY-19318). Fmoc-Val-Cit-PAB is a cleavable antibody-conjugated active molecule (ADC) commonly used linker.

HY-20336G

Mc-Val-Cit-PABC-PNP (GMP)	159857-81-5	ADC Linker
Mc-Val-Cit-PABC-PNP GMP is a GMP grade Mc-Val-Cit-PABC-PNP (HY-20336). Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker. Mc-Val-Cit-PABC-PNP can be used in the synthesis of antibody-drug conjugates (ADCs).

HY-42972G

DBCO-acid (GMP)	1353016-70-2	ADC Linker
DBCO-acid GMP is a GMP grade DBCO-acid (HY-42972). DBCO-acid is a cleavable ADC linker used in the synthesis of ADC linker DBCO-NHS ester (HY-115524 and HY-115545), and agent-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690). DBCO-acid is a click chemistry reagent, itcontains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-44980G

Fmoc-Gly-NH-CH2-acetyloxy (GMP)	1599440-06-8	ADC Linker
Fmoc-Gly-NH-CH2-acetyloxy GMP is a GMP grade Fmoc-Gly-NH-CH2-acetyloxy (HY-44980). Fmoc-Gly-NH-CH2-acetyloxy is a cleavable linker that can be used to synthesize antiboy-drug Conjugates (ADCs).

HY-45672G

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP)	1599440-20-6	ADC Linker
Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-45672). Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC Linker that can be used to synthesize Drug-Linker Conjugates for ADC. Especially for the synthesis of Deruxtecan (HY-13631E), a toxic drug-linker conjugate.

HY-78736G

Val-Cit-PAB-OSBT (GMP)	2210262-26-1	ADC Linker
Val-Cit-PAB-OSBT GMP is a GMP grade Val-Cit-PAB-OSBT (HY-78736). Val-Cit-PAB-OSBT is a degradable ADC linker, which is composed of the polypeptide Val-Cit-PAB and OSBT groups coupled together.

Name	CAS	Type	FDA DMF Filing status
MC-Val-Cit-PAB	159857-80-4	Intermediate of MC-Val-Cit-PAB-MMAE	Sec-DMF#035550
Boc-Dap-NE	160800-65-7	Intermediate of MMAE	Sec-DMF#035548
Fmoc-3VVD-OH	863971-44-2	Intermediate of MMAE	Sec-DMF#035549
VcMMAE	646502-53-6	Linker+Payload	Sec-DMF#036740
Exatecan Mesylate	169869-90-3	Payload	Sec-DMF#036708

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GMP Small molecules for Antibody-drug Conjugate(ADC)

Products (24)

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