2. PROTAC
  3. Ligands for E3 Ligase
  4. GNE7599

GNE7599 is a high-affinity and orally active von Hippel-Lindau (VHL) ligand with a Kd of 540 pM. GNE7599 can be connected to the ligand for protein by a linker to form PROTACs.

For research use only. We do not sell to patients.

GNE7599 Chemical Structure

GNE7599 Chemical Structure

CAS No. : 2771069-76-0

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GNE7599 Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

GNE7599 is a high-affinity and orally active von Hippel-Lindau (VHL) ligand with a Kd of 540 pM. GNE7599 can be connected to the ligand for protein by a linker to form PROTACs[1].

Molecular Weight

576.75

Formula

C31H40N6O3S
CAS No.
SMILES

O=C([C@@H](N1N=NC(C2CC2)=C1)C(C)(C)C)N3C[C@H](O)C[C@H]3C(N[C@H]4CCCCC5=C4C=CC(C6=C(C)N=CS6)=C5)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GNE7599 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GNE75992771069-76-0GNE 7599GNE-7599Ligands for E3 LigaseE3 ligase-recruiting MoietyVHL Ligandorally activePROTACInhibitorinhibitorinhibit

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