2. Apoptosis
  3. Apoptosis
  4. Goniothalamin

Goniothalamin  (Synonyms: GTN; (R)-(+)-Goniothalamin)

Cat. No.: HY-N3968 Purity: ≥98.0%
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Goniothalamin (GTN) is styryllactone with anticancer, anti-inflammatory, immunosuppressive properties. Goniothalamin induces cytotoxicity, DNA damage and apoptosis of a variety of cancer cell lines.

For research use only. We do not sell to patients.

Goniothalamin Chemical Structure

Goniothalamin Chemical Structure

CAS No. : 17303-67-2

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Based on 1 publication(s) in Google Scholar

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Description

Goniothalamin (GTN) is styryllactone with anticancer, anti-inflammatory, immunosuppressive properties. Goniothalamin induces cytotoxicity, DNA damage and apoptosis of a variety of cancer cell lines[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
5.7 μM
Compound: (R)-1
Antiproliferative activity against human A549 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human A549 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 28214230]
DU-145 IC50
19 μM
Compound: 1a
Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
[PMID: 19022676]
HaCaT IC50
28.6 μM
Compound: 1
Cytotoxicity against human HaCaT cells assessed as reduction in cell viability after 24 hrs by MTT reduction assay
Cytotoxicity against human HaCaT cells assessed as reduction in cell viability after 24 hrs by MTT reduction assay
[PMID: 25305718]
HBL-100 IC50
20.9 μM
Compound: (R)-1
Antiproliferative activity against human HBL100 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human HBL100 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 28214230]
HepG2 IC50
0.625 μM
Compound: 1
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 to 72 hrs
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 to 72 hrs
[PMID: 31306909]
HepG2 IC50
1.6 μM
Compound: 1
Cytotoxicity against human HepG2 cells after 24 hrs
Cytotoxicity against human HepG2 cells after 24 hrs
[PMID: 20392543]
K562 IC50
7 μM
Compound: Goniothalamin
Inhibition of NF-kappaB transactivation in TNF-alpha-stimulated human K562 cells preincubated for 2 hrs followed by TNF-alpha challenge measured after 6 hrs by dual luciferase reporter gene assay
Inhibition of NF-kappaB transactivation in TNF-alpha-stimulated human K562 cells preincubated for 2 hrs followed by TNF-alpha challenge measured after 6 hrs by dual luciferase reporter gene assay
[PMID: 24775915]
LNCaP IC50
12 μM
Compound: 1a
Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay
Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay
[PMID: 19022676]
MCF7 IC50
28 μM
Compound: 1a
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 19022676]
MCF7 IC50
4.5 μM
Compound: 1
Cytotoxicity against human MCF7 cells after 24 hrs
Cytotoxicity against human MCF7 cells after 24 hrs
[PMID: 20392543]
MCF7 IC50
55.5 μM
Compound: (R)-1
Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 28214230]
PANC-1 IC50
65 μM
Compound: 1
Antiproliferative activity against human PANC1 cells assessed as reduction in colonies after 15 days by colony assay
Antiproliferative activity against human PANC1 cells assessed as reduction in colonies after 15 days by colony assay
[PMID: 25305718]
PANC-1 IC50
65 μM
Compound: 1
Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 24 hrs by MTT reduction assay
Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 24 hrs by MTT reduction assay
[PMID: 25305718]
PC-3 IC50
4 μM
Compound: 1a
Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
[PMID: 19022676]
RAW264.7 IC50
27.4 μM
Compound: 1
Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells after 18 hrs by luciferase assay
Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells after 18 hrs by luciferase assay
[PMID: 23735825]
RAW264.7 IC50
34.2 μM
Compound: 1
Cytotoxicity against mouse RAW264.7 cells after 18 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells after 18 hrs by MTT assay
[PMID: 23735825]
Clinical Trial
Molecular Weight

200.23

Formula

C13H12O2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1C=CC[C@H](/C=C/C2=CC=CC=C2)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (247 KB)

Handling Instructions (2659 KB)
References
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Goniothalamin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Goniothalamin17303-67-2GTN (R)-(+)-GoniothalaminApoptosisanticancerimmunosuppressivecytotoxicityDNA damageapoptosisInhibitorinhibitorinhibit

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