2. GPCR/G Protein
  3. EBI2/GPR183
  4. GPR183-IN-2

GPR183-IN-2 (compound 23) is a potent GPR183 inhibitor. GPR183-IN-2 inhibits Ca2+ mobilization with an IC50 value of 39.45 nM. GPR183-IN-2 has the potential for the research of cancer, autoimmune diseases, pain, and osteoporosis.

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GPR183-IN-2 Chemical Structure

GPR183-IN-2 Chemical Structure

CAS No. : 2924064-10-6

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Based on 1 publication(s) in Google Scholar

GPR183-IN-2 Related Antibodies

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Description

GPR183-IN-2 (compound 23) is a potent GPR183 inhibitor. GPR183-IN-2 inhibits Ca2+ mobilization with an IC50 value of 39.45 nM. GPR183-IN-2 has the potential for the research of cancer, autoimmune diseases, pain, and osteoporosis[1].

In Vivo

Pharmacokinetic Parameters[1].

Parameters CL (mL/min/kg) T1/2 (h) Cmax (ng/mL) AUC0-t (ng•h/mL) Vss (L/kg) F (%)
IV 1 mg/kg 10.17 1.91 965 1575 1.50 -
PO 10 mg/kg - 4.58 5108 28042 - 224.50

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

407.30

Formula

C19H23BrN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1CCOCC1)N2CCN(CC2)C(/C=C/C3=CC=C(C=C3)Br)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.75 mg/mL (21.48 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4552 mL 12.2760 mL 24.5519 mL
5 mM 0.4910 mL 2.4552 mL 4.9104 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4552 mL 12.2760 mL 24.5519 mL 61.3798 mL
5 mM 0.4910 mL 2.4552 mL 4.9104 mL 12.2760 mL
10 mM 0.2455 mL 1.2276 mL 2.4552 mL 6.1380 mL
15 mM 0.1637 mL 0.8184 mL 1.6368 mL 4.0920 mL
20 mM 0.1228 mL 0.6138 mL 1.2276 mL 3.0690 mL
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GPR183-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPR183-IN-22924064-10-6EBI2/GPR183orally activityCa2+ mobilizationU937 cellscancerautoimmune diseasespainosteoporosisInhibitorinhibitorinhibit

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