GR127935 hydrochloride

Cat. No.: HY-100794 Purity: 99.38%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

GR127935 hydrochloride is a potent and orally active 5-HT1D and 5-HT1B receptor antagonist with pKis of 8.5 for both isoforms. GR127935 hydrochloride has 100-fold selectivity for 5-HT1B/1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors. GR127935 hydrochloride can be used in neurological disease research.

For research use only. We do not sell to patients.

GR127935 hydrochloride Chemical Structure

CAS No. : 148642-42-6

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of GR127935 hydrochloride:

GR127935 Get quote

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View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

5-HT_1B Receptor

8.5 (pKi)

5-HT_1D Receptor

8.5 (pIC₅₀)

Molecular Weight

534.05

Formula

C₂₉H₃₂ClN₅O₃

CAS No.

148642-42-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C2=CC=C(C3=NOC(C)=N3)C=C2C)C=C1)NC4=CC=C(OC)C(N5CCN(C)CC5)=C4.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL (156.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8725 mL	9.3624 mL	18.7248 mL
5 mM	0.3745 mL	1.8725 mL	3.7450 mL
10 mM	0.1872 mL	0.9362 mL	1.8725 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.38%

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Data Sheet (270 KB) SDS (393 KB)

COA (247 KB) HNMR (284 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. J W Clitherow, et al. Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists. J Med Chem. 1994 Jul 22;37(15):2253-7. [Content Brief]

[2]. Mohammad Nasehi, et al. Possible involvement of CA1 5-HT1B/1D and 5-HT2A/2B/2C receptors in harmaline-induced amnesia. Pharmacol Biochem Behav. 2014 Oct;125:70-77. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8725 mL	9.3624 mL	18.7248 mL	46.8121 mL
	5 mM	0.3745 mL	1.8725 mL	3.7450 mL	9.3624 mL
	10 mM	0.1872 mL	0.9362 mL	1.8725 mL	4.6812 mL
	15 mM	0.1248 mL	0.6242 mL	1.2483 mL	3.1208 mL
	20 mM	0.0936 mL	0.4681 mL	0.9362 mL	2.3406 mL
	25 mM	0.0749 mL	0.3745 mL	0.7490 mL	1.8725 mL
	30 mM	0.0624 mL	0.3121 mL	0.6242 mL	1.5604 mL
	40 mM	0.0468 mL	0.2341 mL	0.4681 mL	1.1703 mL
	50 mM	0.0374 mL	0.1872 mL	0.3745 mL	0.9362 mL
	60 mM	0.0312 mL	0.1560 mL	0.3121 mL	0.7802 mL
	80 mM	0.0234 mL	0.1170 mL	0.2341 mL	0.5852 mL
	100 mM	0.0187 mL	0.0936 mL	0.1872 mL	0.4681 mL