2. PI3K/Akt/mTOR Stem Cell/Wnt Neuronal Signaling
  3. GSK-3 Tau Protein β-catenin
  4. GSK-3β inhibitor 24

GSK-3β inhibitor 24 (Compound 41) is a potent GSK-3β inhibitor with IC50 of 0.22 nM. GSK-3β inhibitor 24 increases GSK-3β phosphorylation at Ser9 site dose-dependently. GSK-3β inhibitor 24 inhibits the hyperphosphorylation of tau protein by decreasing the p-tau-Ser396 abundance. GSK-3β inhibitor 24 up-regulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2). GSK-3β inhibitor 24 demonstrates remarkable anti-Alzheimer's disease (AD) effects.

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GSK-3β inhibitor 24 Chemical Structure

GSK-3β inhibitor 24 Chemical Structure

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GSK-3β inhibitor 24 Related Antibodies

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Description

GSK-3β inhibitor 24 (Compound 41) is a potent GSK-3β inhibitor with IC50 of 0.22 nM. GSK-3β inhibitor 24 increases GSK-3β phosphorylation at Ser9 site dose-dependently. GSK-3β inhibitor 24 inhibits the hyperphosphorylation of tau protein by decreasing the p-tau-Ser396 abundance. GSK-3β inhibitor 24 up-regulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2). GSK-3β inhibitor 24 demonstrates remarkable anti-Alzheimer's disease (AD) effects[1].

IC50 & Target[1]

GSK-3β

0.22 nM (IC50)

Molecular Weight

434.45

Formula

C26H18N4O3
SMILES

O=C(C1=CNC2=C1C=C(C=N2)C3=CC=CC=C3)NC4=C(C=CN=C4)C5=CC=C6OCOC6=C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GSK-3β inhibitor 24 Related Classifications

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Keywords:

GSK-3β inhibitor 24GSK-3Tau Proteinβ-cateninGlycogen synthase kinase-3Glycogen synthase kinase 3Beta cateninAlzheimer's diseaseSH-SY5Y cellsZebrafishC57BL/6Low‐toxicitydyskinesiaAnti-AD.Inhibitorinhibitorinhibit

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