2. MAPK/ERK Pathway
  3. MEK
  4. GSK1790627

GSK1790627 is the N-deacetylated metabolite of Trametinib (HY-10999). Trametinib is an orally active MEK inhibitor, and activates autophagy and induces apoptosis.

For research use only. We do not sell to patients.

GSK1790627 Chemical Structure

GSK1790627 Chemical Structure

CAS No. : 871701-87-0

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5 mg USD 260 In-stock
10 mg USD 380 In-stock
25 mg USD 800 In-stock
50 mg USD 1280 In-stock
100 mg USD 2100 In-stock
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Based on 1 publication(s) in Google Scholar

GSK1790627 Related Antibodies

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Description

GSK1790627 is the N-deacetylated metabolite of Trametinib (HY-10999). Trametinib is an orally active MEK inhibitor, and activates autophagy and induces apoptosis[1].

In Vitro

GSK1790627 (1, 10 and 50 μM, 60 min) is stable in the presence of recombinant hNAT enzymes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GSK1790627 Related Antibodies
Molecular Weight

573.36

Formula

C24H21FIN5O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC=CC(N)=C2)C(C(C(N1C3CC3)=O)=C(NC4=CC=C(I)C=C4F)N5C)=C(C)C5=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMF : 10 mg/mL (17.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7441 mL 8.7205 mL 17.4410 mL
5 mM 0.3488 mL 1.7441 mL 3.4882 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 1.7441 mL 8.7205 mL 17.4410 mL 43.6026 mL
5 mM 0.3488 mL 1.7441 mL 3.4882 mL 8.7205 mL
10 mM 0.1744 mL 0.8721 mL 1.7441 mL 4.3603 mL
15 mM 0.1163 mL 0.5814 mL 1.1627 mL 2.9068 mL
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GSK1790627 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK1790627871701-87-0GSK 1790627GSK-1790627MEKMitogen-activated protein kinase kinaseMAPKKMAP2KTrametinib metaboliteN-deacetylatedInhibitorinhibitorinhibit

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