2. Epigenetics
  3. Histone Methyltransferase
  4. GSK591 hydrochloride

GSK591 hydrochloride  (Synonyms: EPZ015866 hydrochloride; GSK3203591 hydrochloride)

Cat. No.: HY-100235A
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GSK591 (EPZ015866) hydrochloride is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC50 of 4 nM.

For research use only. We do not sell to patients.

GSK591 hydrochloride Chemical Structure

GSK591 hydrochloride Chemical Structure

CAS No. : 2320953-89-5

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GSK591 hydrochloride Related Antibodies

Top Publications Citing Use of Products

    GSK591 hydrochloride purchased from MedChemExpress. Usage Cited in: Exp Cell Res. 2022 Nov 16;422(1):113413.  [Abstract]

    GSK591 (PRMT5i; 200-1000 nM) in combination with EPZ020411 (PRMT6i; 200-1000 nM) exhibits a synergistic anti-proliferative effect on HCT116 and SW620 cells.

    View All Histone Methyltransferase Isoform Specific Products:

    View All Isoforms
    EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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    Description

    GSK591 (EPZ015866) hydrochloride is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC50 of 4 nM[1].

    IC50 & Target

    IC50: 4 nM (PRMT5)[1]
    Molecular Weight

    453.41

    Formula

    C22H30Cl2N4O2
    CAS No.
    SMILES

    O=C(C1=CC(NC2CCC2)=NC=C1)NC[C@H](O)CN3CC4=C(C=CC=C4)CC3.Cl.Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
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    GSK591 hydrochloride Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    GSK5912320953-89-5EPZ015866GSK3203591GSK 591GSK-591EPZ 015866EPZ-015866GSK 3203591GSK-3203591Histone MethyltransferaseInhibitorinhibitorinhibit

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