Guanethidine

Cat. No.: HY-B1251: FAQs
Data Sheet Handling Instructions

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Guanethidine sulphate was synthesized in 1959. Guanethidine is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.

For research use only. We do not sell to patients.

Guanethidine Chemical Structure

CAS No. : 55-65-2

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Other In-stock Forms of Guanethidine:

Guanethidine sulfate

Other Forms of Guanethidine:

Guanethidine sulfate In-stock
Guanethidine sesquisulfate Get quote

1 Publications Citing Use of MCE Guanethidine

•Authorea. September 19, 2022.

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Biological Activity
Purity & Documentation
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Description

In Vitro

Ablation of sympathetic fibers is associated with a loss of rat endothelial cell marker (RECA), but no significant effect of guanethidine was found on the survival of endothelial cells and mesenchymal stem cells in vitro^[1].
.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Guanethidine (30 mg/kg, s.c., 1 h) unaffected IL-18 hypernociception in TNFR1^(-/-) mice as a sympathetic blocker^[2].
.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wild-type (WT) Balb/c,TNFR1^(-/-)and IFN_-γ-γ^(-/-) mice^[2].
Dosage:	30 mg/kg
Administration:	Guanethidine (30 mg/kg, s.c., 1 h, diluted in saline)
Result:	Pre-treatment with guanethidine (sympathetic blocker) unaffected IL-18 hypernociception in TNFR1^(-/-) mice.

Molecular Weight

198.31

Formula

C₁₀H₂₂N₄

CAS No.

55-65-2

SMILES

NC(NCCN1CCCCCCC1)=N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. P Dubový, etal. Local chemical sympathectomy of rat bone marrow and its effect on marrow cell composition. [Content Brief]

[2]. Waldiceu A.VerriJr, etal. Antigen-induced inflammatory mechanical hypernociception in mice is mediated by IL-18. Brain Beha [Content Brief]

Guanethidine Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guanethidine55-65-2Adrenergic ReceptorBeta ReceptorGuanethidine hypotensiveInhibitorinhibitorinhibit

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