Guanfacine-d₂ hydrochloride

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Guanfacine-d₂ (hydrochloride) is the deuterium labeled Guanfacine hydrochloride. Guanfacine hydrochloride, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors.

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Guanfacine-d<sub>2</sub> hydrochloride Chemical Structure

Guanfacine-d₂ hydrochloride Chemical Structure

CAS No. : 1398065-88-7

Size	Price	Stock	Quantity
500 μg	USD 400	Get quote 3 - 4 weeks 4 - 5 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
1 mg	USD 695	Get quote 3 - 4 weeks 4 - 5 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Guanfacine-d₂ hydrochloride:

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Biological Activity
Purity & Documentation
References
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Description	Guanfacine-d₂ (hydrochloride) is the deuterium labeled Guanfacine hydrochloride. Guanfacine hydrochloride, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors^[1]^[2].
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Guanfacine-d₂ hydrochloride Related Antibodies
Molecular Weight	284.57
Formula	C₉H₈D₂Cl₃N₃O
CAS No.	1398065-88-7
Unlabeled CAS	29110-48-3
SMILES	N=C(N)NC(C([2H])([2H])C1=C(C=CC=C1Cl)Cl)=O.Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Wang J, et al. Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion. J Neurosci Res. 2010 Mar;88(4):807-15. [Content Brief] [2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]