Guanosine-5 '- monophosphate-¹⁵N₅ sodium

Name: Guanosine-5 '- monophosphate- 15 N 5 sodium
Brand: MedChemExpress
SKU: HY-150642S
Rating: 4.5 (1 reviews)

Cat. No.: HY-150642S Purity: 99.5%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Guanosine-5 '- monophosphate-¹⁵N₅ (sodium) is the ¹⁵N labeled Guanosine-5 '- monophosphate sodium[1].

For research use only. We do not sell to patients.

Guanosine-5 '- monophosphate-<sup>15</sup>N<sub>5</sub> sodium Chemical Structure

Guanosine-5 '- monophosphate-¹⁵N₅ sodium Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Guanosine-5 '- monophosphate-¹⁵N₅ sodium

•Nat Chem Biol. 2024 Jul 26. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Guanosine-5 '- monophosphate-¹⁵N₅ (sodium) is the ¹⁵N labeled Guanosine-5 '- monophosphate sodium[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

412.15

Formula

C₁₀H₁₂¹⁵N₅Na₂O₈P

Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C([15N]=C([15NH]1)[15NH2])[15N](C=[15N]2)[C@]3(O[C@]([H])([C@@]([H])([C@]3(O)[H])O)COP(O[Na])(O[Na])=O)[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 10 mg/mL (24.26 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4263 mL	12.1315 mL	24.2630 mL
5 mM	0.4853 mL	2.4263 mL	4.8526 mL
10 mM	0.2426 mL	1.2132 mL	2.4263 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.5%

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Data Sheet (273 KB) SDS (252 KB)

COA (253 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.4263 mL	12.1315 mL	24.2630 mL	60.6575 mL
	5 mM	0.4853 mL	2.4263 mL	4.8526 mL	12.1315 mL
	10 mM	0.2426 mL	1.2132 mL	2.4263 mL	6.0658 mL
	15 mM	0.1618 mL	0.8088 mL	1.6175 mL	4.0438 mL
	20 mM	0.1213 mL	0.6066 mL	1.2132 mL	3.0329 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.