2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. GW7604

GW7604 is an antiestrogen. GW7604 is the metabolite of GW5638, which is a high affinity estrogen receptor (ER) antagonist.

For research use only. We do not sell to patients.

GW7604 Chemical Structure

GW7604 Chemical Structure

CAS No. : 361203-06-7

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10 mM * 1 mL in DMSO USD 473 In-stock
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10 mg USD 690 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of GW7604:

GW7604 Related Antibodies

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

GW7604 is an antiestrogen. GW7604 is the metabolite of GW5638, which is a high affinity estrogen receptor (ER) antagonist[1].

In Vitro

GW7604 is the presumed metabolite of GW5638 in breast (MCF-7) and endometrial (ECC-1) cell lines. GW7604 (0.1 nM-1 μM; 24 hours) inhibits both Estradiol (1 nM) and 4-hydroxytamoxifen (4-OHT; 10 and 100 nM) induction of TGF-alpha in a concentration related manner (1-1000 nM) in MDA-MB-231 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GW7604 Related Antibodies

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM
Incubation Time: 24 hours
Result: Blocked the effect of estradiol (E2; 1 n M) in a concentration-related manner.
Molecular Weight

370.44

Formula

C25H22O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)/C=C/C1=CC=C(/C(C2=CC=C(O)C=C2)=C(C3=CC=CC=C3)\CC)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

SDS (251 KB)

COA (248 KB)

Handling Instructions (2659 KB)
References
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GW7604 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW7604361203-06-7GW 7604GW-7604Estrogen Receptor/ERRInhibitorinhibitorinhibit

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HY-117153
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