2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. GW7604

GW7604 is an antiestrogen. GW7604 is the metabolite of GW5638, which is a high affinity estrogen receptor (ER) antagonist.

For research use only. We do not sell to patients.

GW7604 Chemical Structure

GW7604 Chemical Structure

CAS No. : 361203-06-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of GW7604:

GW7604 Related Antibodies

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • Biological Activity

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Description

GW7604 is an antiestrogen. GW7604 is the metabolite of GW5638, which is a high affinity estrogen receptor (ER) antagonist[1].

In Vitro

GW7604 is the presumed metabolite of GW5638 in breast (MCF-7) and endometrial (ECC-1) cell lines. GW7604 (0.1 nM-1 μM; 24 hours) inhibits both Estradiol (1 nM) and 4-hydroxytamoxifen (4-OHT; 10 and 100 nM) induction of TGF-alpha in a concentration related manner (1-1000 nM) in MDA-MB-231 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GW7604 Related Antibodies

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM
Incubation Time: 24 hours
Result: Blocked the effect of estradiol (E2; 1 n M) in a concentration-related manner.
Molecular Weight

370.44

Formula

C25H22O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)/C=C/C1=CC=C(/C(C2=CC=C(O)C=C2)=C(C3=CC=CC=C3)\CC)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (67.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6995 mL 13.4975 mL 26.9949 mL
5 mM 0.5399 mL 2.6995 mL 5.3990 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (251 KB)

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6995 mL 13.4975 mL 26.9949 mL 67.4873 mL
5 mM 0.5399 mL 2.6995 mL 5.3990 mL 13.4975 mL
10 mM 0.2699 mL 1.3497 mL 2.6995 mL 6.7487 mL
15 mM 0.1800 mL 0.8998 mL 1.7997 mL 4.4992 mL
20 mM 0.1350 mL 0.6749 mL 1.3497 mL 3.3744 mL
25 mM 0.1080 mL 0.5399 mL 1.0798 mL 2.6995 mL
30 mM 0.0900 mL 0.4499 mL 0.8998 mL 2.2496 mL
40 mM 0.0675 mL 0.3374 mL 0.6749 mL 1.6872 mL
50 mM 0.0540 mL 0.2699 mL 0.5399 mL 1.3497 mL
60 mM 0.0450 mL 0.2250 mL 0.4499 mL 1.1248 mL
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GW7604 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW7604361203-06-7GW 7604GW-7604Estrogen Receptor/ERRInhibitorinhibitorinhibit

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