H-Gly-Sar-Sar-OH 

H-Gly-Sar-Sar-OH is an orally active tripeptide. H-Gly-Sar-Sar-OH is transported through PepT1 within Caco-2 cells. H-Gly Sar Sar OH has potential applications in material transportation^[1][2][3].

H-Gly-Sar-Sar-OH (0.1 mM; perfusion; single dose) is insignificantly hydrolyzed (administered for 60 min) or cleared in the kidneys of Sprague-Dawley rats^[2].
H-Gly-Sar-Sar-OH (10 mg/kg; p.o.; single dose) shows stability in spontaneously hypertensive rats (SHRs)^[3].
Pharmacokinetic (PK) parameters of H-Gly-Sar-Sar-OH in SHRs^[3]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

217.22

C₈H₁₅N₃O₄

57836-11-0

H-Gly-Sar-Sar-OH

G-{Sar}-{Sar}

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hong SM, et al. Structural Design of Oligopeptides for Intestinal Transport Model. J Agric Food Chem. 2016 Mar 16;64(10):2072-9.  [Content Brief]

  [2]. Minami H, et al. Oligopeptides: mechanism of renal clearance depends on molecular structure. Am J Physiol. 1992 Jul;263(1 Pt 2):F109-15.  [Content Brief]

  [3]. Hanh VT, et al. Effect of Aging on the Absorption of Small Peptides in Spontaneously Hypertensive Rats. J Agric Food Chem. 2017 Jul 26;65(29):5935-5943.  [Content Brief]