H1k

Cat. No.: HY-149261: FAQs
Data Sheet Handling Instructions

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H1k, a Eudistomin Y derivative, is a lysosome-targeted antiproliferation agent. H1k increases the autophagy signal and downregulate the expression of cyclin-dependent kinase (CDK1) and cyclin B1. H1k can be used in research of cancer.

For research use only. We do not sell to patients.

H1k Chemical Structure

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

H1k (72 h) has antiproliferation activity against LS-180, HepG-2, SGC-7901, A549 and MDA-MB-231 cells with IC₅₀ values of 2.9, 9.6, 12.1, 14.8, and 20.5 μM, respectively^[1].
H1k (0-50 μM; 24 h) triggers a distinct G2-M arrest in the MDA-MB-231 and SGC-7901 cells in a dose-dependent manner^[1].
H1k (0-20 μM; 6 h; MDA-MB-231 cells) induces autophagy to exert its antiproliferative activity, and lysosomes are its functional targets^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:	MDA-MB-231 and SGC-7901 cells
Concentration:	0, 5, 10, 20, 50 μM
Incubation Time:	24 hours
Result:	Arrested cell cycle at G2-M period in a dose-dependent manner.

Western Blot Analysis^[1]

Cell Line:	MDA-MB-231 and SGC-7901 cells
Concentration:	0, 5, 10, and 20 μM
Incubation Time:	6 hours
Result:	Increased the LC3B-I and LC3B-II levels at MDA-MB-231 cells in a dose-dependent manner.

Western Blot Analysis^[1]

Cell Line:	MDA-MB-231 and SGC-7901 cells
Concentration:	0, 5, 10, 20, 50 μM
Incubation Time:	6 hours
Result:	Inhibited antiproliferation of cancer cells and the downregulation of CDK1 and cyclin B1.

Molecular Weight

392.45

Formula

C₂₆H₂₀N₂O₂

SMILES

COC1=CC=C(C=C1)CN2C3=C(C4=C2C(C(C5=CC=CC=C5)=O)=NC=C4)C=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yang G, et, al. Design, synthesis, and discovery of Eudistomin Y derivatives as lysosome-targeted antiproliferation agents. Eur J Med Chem. 2023 Mar 15;250:115193. [Content Brief]

H1k Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H1kAutophagyCDKCyclin dependent kinaselysosomeantiproliferationcyclin-dependent kinasecyclin B1G2-MInhibitorinhibitorinhibit

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