1. Autophagy Cell Cycle/DNA Damage
  2. Autophagy CDK
  3. H1k

H1k, a Eudistomin Y derivative, is a lysosome-targeted antiproliferation agent. H1k increases the autophagy signal and downregulate the expression of cyclin-dependent kinase (CDK1) and cyclin B1. H1k can be used in research of cancer.

For research use only. We do not sell to patients.

H1k Chemical Structure

H1k Chemical Structure

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Description

H1k, a Eudistomin Y derivative, is a lysosome-targeted antiproliferation agent. H1k increases the autophagy signal and downregulate the expression of cyclin-dependent kinase (CDK1) and cyclin B1. H1k can be used in research of cancer[1].

In Vitro

H1k (72 h) has antiproliferation activity against LS-180, HepG-2, SGC-7901, A549 and MDA-MB-231 cells with IC50 values of 2.9, 9.6, 12.1, 14.8, and 20.5 μM, respectively[1].
H1k (0-50 μM; 24 h) triggers a distinct G2-M arrest in the MDA-MB-231 and SGC-7901 cells in a dose-dependent manner[1].
H1k (0-20 μM; 6 h; MDA-MB-231 cells) induces autophagy to exert its antiproliferative activity, and lysosomes are its functional targets[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 and SGC-7901 cells
Concentration: 0, 5, 10, 20, 50 μM
Incubation Time: 24 hours
Result: Arrested cell cycle at G2-M period in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 and SGC-7901 cells
Concentration: 0, 5, 10, and 20 μM
Incubation Time: 6 hours
Result: Increased the LC3B-I and LC3B-II levels at MDA-MB-231 cells in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 and SGC-7901 cells
Concentration: 0, 5, 10, 20, 50 μM
Incubation Time: 6 hours
Result: Inhibited antiproliferation of cancer cells and the downregulation of CDK1 and cyclin B1.
Molecular Weight

392.45

Formula

C26H20N2O2

SMILES

COC1=CC=C(C=C1)CN2C3=C(C4=C2C(C(C5=CC=CC=C5)=O)=NC=C4)C=CC=C3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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H1k
Cat. No.:
HY-149261
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