2. Neuronal Signaling
  3. Beta-secretase Cholinesterase (ChE)
  4. hAChE/hBACE-1-IN-3

hAChE/hBACE-1-IN-3 (Compound 23a) is a mixed-type inhibitor of hAChE and hBACE-1 with IC50 values of 0.32 μM and 0.39 μM, respectively, Ki values of 0.26 μM and 0.46 μM, respectively. hAChE/hBACE-1-IN-3 can penetrate the blood-brain barrier.

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hAChE/hBACE-1-IN-3 Chemical Structure

hAChE/hBACE-1-IN-3 Chemical Structure

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hAChE/hBACE-1-IN-3 Related Antibodies

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BACE1 BACE2

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AChE BChE

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Description

hAChE/hBACE-1-IN-3 (Compound 23a) is a mixed-type inhibitor of hAChE and hBACE-1 with IC50 values of 0.32 μM and 0.39 μM, respectively, Ki values of 0.26 μM and 0.46 μM, respectively. hAChE/hBACE-1-IN-3 can penetrate the blood-brain barrier[1].

IC50 & Target

IC50: 0.32 μM (hAChE), 0.39 μM (hBACE-1)[1]
Molecular Weight

421.53

Formula

C25H31N3O3
SMILES

O=C(NCCC1CCN(CC2=CC=CC=C2)CC1)C3=CC4=C(N3)C=C(OC)C(OC)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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hAChE/hBACE-1-IN-3 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hAChE/hBACE-1-IN-3Beta-secretaseCholinesterase (ChE)BACEβ-SecretasehAChE/hBACE-1 InhibitorNeurological DiseaseAlzheimer’s DiseaseInhibitorinhibitorinhibit

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