hAChE-IN-3 

hAChE-IN-3 (compounds 5c) is a potent and blood-brain barrier permeable AChE, BuChE， MAO-B-IN-1 and BACE-1 inhibitor, with IC₅₀ values of 0.44, 0.08, 5.15 and 0.38 μM, respectively. hAChE-IN-3 has antioxidant activity and metal chelating ability. In addition, hAChE-IN-3 can bind to peripheral anion sites, and affect β amyloid and reduce Alzheimer's-associated neurodegeneration. hAChE-IN-3 has the potential for the research of Alzheimer's disease^[1].

hAChE-IN-3 (compounds 5c) has IC₅₀ values of 36.28 μM (24 h) for SH-SY5Y cell line and 154.10 μM (48 h) for HepG2 cell line^[1].
hAChE-IN-3 has IC₅₀ values of 2.58 μM of inhibition of Aβ Aggregation and 59% inhibition at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

541.98

C₃₀H₂₄ClN₃O₅

2983723-56-2

O=C(C1=CC=C(Cl)C=C1)COC2=CC3=C(C=C2)C(C4=CC=CC([N+]([O-])=O)=C4)C5=C(N)C6=C(N=C5O3)CCCC6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Salma Fares，et al. Modified Tacrine Derivatives as Multitarget-Directed Ligands for the Treatment of Alzheimer’sDisease: Synthesis, Biological Evaluation, and Molecular Modeling Study. ACS Omega 2023, 8, 29, 26012–26034.