2. Metabolic Enzyme/Protease Neuronal Signaling
  3. Carbonic Anhydrase Cholinesterase (ChE)
  4. hBChE-IN-4

hBChE-IN-4 (compound 40) is a potent hCA activator and BChE inhibitor with KA values of 266, 76.9, 918, 893, 98.0 nM for hCA I, hCA II, hCA IV, hCA VB, hCA VII, IC50 values of 72.1, 4.2 nM for eeAChE, eqBChE, respectively. hBChE-IN-4 shows no cytotoxicity. hBChE-IN-4 shows potent procognitive effects. hBChE-IN-4 has the potential for the research of neurodegenerative diseases and other neuropsychiatric disorders.

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hBChE-IN-4 Chemical Structure

hBChE-IN-4 Chemical Structure

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hBChE-IN-4 Related Antibodies

Top Publications Citing Use of Products

View All Carbonic Anhydrase Isoform Specific Products:

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CA CA I CA Ⅱ CA Ⅸ CA XII

View All Cholinesterase (ChE) Isoform Specific Products:

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AChE BChE

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Description

hBChE-IN-4 (compound 40) is a potent hCA activator and BChE inhibitor with KA values of 266, 76.9, 918, 893, 98.0 nM for hCA I, hCA II, hCA IV, hCA VB, hCA VII, IC50 values of 72.1, 4.2 nM for eeAChE, eqBChE, respectively. hBChE-IN-4 shows no cytotoxicity. hBChE-IN-4 shows potent procognitive effects. hBChE-IN-4 has the potential for the research of neurodegenerative diseases and other neuropsychiatric disorders[1].

IC50 & Target

EeAChE

72.1 nM (IC50)

eqBCHE

4.2 nM (IC50)

hCA I

266 nM (KA)

hCA II

76.9 nM (KA)

hCA VB

893 nM (KA)

hCA IV

918 nM (KA)

hCA VII

98.0 nM (KA)

Molecular Weight

449.59

Formula

C26H35N5O2
SMILES

O=C([C@@H](NCCCCCCNC1=C2CCCCC2=NC3=CC=CC=C31)CC4=CNC=N4)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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hBChE-IN-4 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hBChE-IN-4Carbonic AnhydraseCholinesterase (ChE)Carbonate dehydrataseSH-SY5Y cellspotent procognitive effectsROSneuropsychiatric disordersInhibitorinhibitorinhibit

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