2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC-IN-52

HDAC-IN-52 is a pyridine-containing HDAC inhibitor, with IC50s of 0.189, 0.227, 0.440 and 0.446 μM for HDAC1, HDAC2, HDAC3, and HDAC10, respectively. HDAC-IN-52 can be used for the research of cancer.

For research use only. We do not sell to patients.

HDAC-IN-52 Chemical Structure

HDAC-IN-52 Chemical Structure

CAS No. : 2075787-77-6

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1 mg USD 220 In-stock
5 mg USD 485 In-stock
10 mg USD 710 In-stock
25 mg USD 1100 In-stock
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Based on 1 publication(s) in Google Scholar

HDAC-IN-52 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC-IN-52 is a pyridine-containing HDAC inhibitor, with IC50s of 0.189, 0.227, 0.440 and 0.446 μM for HDAC1, HDAC2, HDAC3, and HDAC10, respectively. HDAC-IN-52 can be used for the research of cancer[1].

IC50 & Target[1]

hHDAC1

0.189 μM (IC50)

hHDAC2

0.227 μM (IC50)

hHDAC3

0.440 μM (IC50)

hHDAC10

0.446 μM (IC50)

In Vitro

HDAC-IN-52 (compound 8f) (72 hours) inhibits the proliferation of HCT116, A549 and K562 cells, with IC50s of 0.43, 1.28, and 0.37 μM, respectively[1].
HDAC-IN-52 (1-5 μM; 24-48 h) induces remarkable leukaemia U937 cell death after 48 h, with 76% and 100% pre-G1 phase arrest, respectively[1].
HDAC-IN-52 (1-5 μM; 48 h) increases mRNA expression of p21, BAX and BAK, downregulated cyclin D1 and BCL-2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-52 Related Antibodies
Molecular Weight

396.44

Formula

C24H20N4O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

NC1=CC=CC=C1NC(C2=NC=C(C=C2)NC(CC3=CC4=C(C=C3)C=CC=C4)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (42.05 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5224 mL 12.6122 mL 25.2245 mL
5 mM 0.5045 mL 2.5224 mL 5.0449 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5224 mL 12.6122 mL 25.2245 mL 63.0612 mL
5 mM 0.5045 mL 2.5224 mL 5.0449 mL 12.6122 mL
10 mM 0.2522 mL 1.2612 mL 2.5224 mL 6.3061 mL
15 mM 0.1682 mL 0.8408 mL 1.6816 mL 4.2041 mL
20 mM 0.1261 mL 0.6306 mL 1.2612 mL 3.1531 mL
25 mM 0.1009 mL 0.5045 mL 1.0090 mL 2.5224 mL
30 mM 0.0841 mL 0.4204 mL 0.8408 mL 2.1020 mL
40 mM 0.0631 mL 0.3153 mL 0.6306 mL 1.5765 mL
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HDAC-IN-52 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-522075787-77-6HDACHistone deacetylasesInhibitorinhibitorinhibit

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