HDAC6-IN-5

Cat. No.: HY-146678: FAQs
Data Sheet Handling Instructions

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HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC₅₀ of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ_1-42 self-aggregation and AChE, with IC₅₀ values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity.

For research use only. We do not sell to patients.

HDAC6-IN-5 Chemical Structure

CAS No. : 2413603-15-1

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•Related Small Molecules:

•Related Proteins:

View All HDAC Isoform Specific Products:

View All Isoforms

HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

View All Cholinesterase (ChE) Isoform Specific Products:

View All Isoforms

AChE BChE

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

AChE

0.72 μM (IC₅₀)

HDAC6

0.026 ± 0. μM (IC₅₀)

HDAC1

0.09 ± 0.0 μM (IC₅₀)

HDAC

0.16 ± 0.0 μM (IC₅₀)

HDAC3

0.33 ± 0. μM (IC₅₀)

HDAC2

0.48 ± 0.0 μM (IC₅₀)

HDAC9

5.51 ± 0.0 μM (IC₅₀)

HDAC5

7.19 ± 0.4 μM (IC₅₀)

HDAC4

7.85 ± 0.6 μM (IC₅₀)

HDAC7

9.13 ± 0.3 μM (IC₅₀)

In Vitro

HDAC6-IN-5 (compound 11b) induces histone H3 and α-tubulin acetylation in a dose-dependent manner, with EC₅₀ values of 0.58 and 8 μM, respectively^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

408.25

Formula

C₂₀H₁₄BrN₃O₂

CAS No.

2413603-15-1

SMILES

O=C(C1=CC=C(C=C1)NC2=C3C=CC=CC3=NC4=CC=C(C=C42)Br)NO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tseng HJ, et al. Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease. Eur J Med Chem. 2020 Apr 15;192:112193. [Content Brief]

HDAC6-IN-5 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-52413603-15-1HDACAmyloid-βCholinesterase (ChE)Histone deacetylasesβ-amyloid peptideAβAbetaNeuro-2a cellsneuroblastomaHistone deacetylaseAcetylcholine esteraseAcridineMultitargetAlzheimer’s disease (AD)Inhibitorinhibitorinhibit

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