2. GPCR/G Protein Immunology/Inflammation Anti-infection
  3. CXCR HIV
  4. HF50731

HF50731 (compound 21) is a potent CXCR4 antagonist. HF50731 shows strong CXCR4 binding affinity, with IC50 of 19.8 nM. HF50731 effectively inhibits calcium mobilization, cell migration, and HIV-1 infection via CXCR4 coreceptor, with IC50 values of 119.2 nM, 621.4 nM and 1.5 μM.

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HF50731 Chemical Structure

HF50731 Chemical Structure

CAS No. : 2484771-19-7

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HF50731 Related Antibodies

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Description

HF50731 (compound 21) is a potent CXCR4 antagonist. HF50731 shows strong CXCR4 binding affinity, with IC50 of 19.8 nM. HF50731 effectively inhibits calcium mobilization, cell migration, and HIV-1 infection via CXCR4 coreceptor, with IC50 values of 119.2 nM, 621.4 nM and 1.5 μM[1].

IC50 & Target

CXCR4

19.8 nM (IC50)

HIV-1

1.5 μM (IC50)

Molecular Weight

414.67

Formula

C26H46N4
CAS No.
SMILES

C1(CNCCCNC2CCCCC2)=CC=C(CNCCCNC3CCCCC3)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HF50731 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HF507312484771-19-7HF 50731HF-50731CXCRHIVCXC chemokine receptorsC-X-C motif chemokine receptorsHuman immunodeficiency virusChemokine receptorCXCR4 antagonistPolyamineHIV-1SDF-1αInhibitorinhibitorinhibit

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