2. PI3K/Akt/mTOR Immunology/Inflammation GPCR/G Protein
  3. Akt CXCR
  4. Hit 14

Hit 14 is an inhibitor for C-X-C chemokine receptor type 4 (CXCR4) with IC50 of 254 nM. Hit 14 inhibits the migration and invasion of cell MDA-MB-231. Hit 14 inhibits the Akt phosphorylation, exhibits anti-inflammatory activity, and ameliorateds the ear swelling and damage in mouse models.

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Hit 14 Chemical Structure

Hit 14 Chemical Structure

CAS No. : 440338-68-1

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Hit 14 Related Antibodies

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Description

Hit 14 is an inhibitor for C-X-C chemokine receptor type 4 (CXCR4) with IC50 of 254 nM. Hit 14 inhibits the migration and invasion of cell MDA-MB-231. Hit 14 inhibits the Akt phosphorylation, exhibits anti-inflammatory activity, and ameliorateds the ear swelling and damage in mouse models[1].

IC50 & Target

12G5 mAb-CXCR4

254 nM (IC50)

Molecular Weight

496.60

Formula

C22H28N2O7S2
CAS No.
SMILES

O=S(C1=CC=C(OC2=CC=C(S(=O)(NCC3OCCC3)=O)C=C2)C=C1)(NCC4OCCC4)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Hit 14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hit 14440338-68-1Hit14Hit-14AktCXCRPKBProtein kinase BCXC chemokine receptorsC-X-C motif chemokine receptorsMDA-MB-231anti-inflammatoryInhibitorinhibitorinhibit

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