2. Anti-infection
  3. HIV Reverse Transcriptase
  4. HIV-1 inhibitor-48

HIV-1 inhibitor-48 (compound 13o) is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) and exhibits anti-HIV-1 activity.

For research use only. We do not sell to patients.

HIV-1 inhibitor-48 Chemical Structure

HIV-1 inhibitor-48 Chemical Structure

CAS No. : 374067-85-3

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5 mg USD 100 In-stock
10 mg USD 140 In-stock
25 mg USD 210 In-stock
50 mg USD 298 In-stock
100 mg USD 470 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

HIV-1 inhibitor-48 (compound 13o) is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) and exhibits anti-HIV-1 activity[1].

Molecular Weight

394.27

Formula

C19H16BrN5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=C(C(=CC(=C1)Br)C)N=C2C=CN=C(NC3=CC=C(C=C3)C#N)N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (317.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5363 mL 12.6817 mL 25.3633 mL
5 mM 0.5073 mL 2.5363 mL 5.0727 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5363 mL 12.6817 mL 25.3633 mL 63.4083 mL
5 mM 0.5073 mL 2.5363 mL 5.0727 mL 12.6817 mL
10 mM 0.2536 mL 1.2682 mL 2.5363 mL 6.3408 mL
15 mM 0.1691 mL 0.8454 mL 1.6909 mL 4.2272 mL
20 mM 0.1268 mL 0.6341 mL 1.2682 mL 3.1704 mL
25 mM 0.1015 mL 0.5073 mL 1.0145 mL 2.5363 mL
30 mM 0.0845 mL 0.4227 mL 0.8454 mL 2.1136 mL
40 mM 0.0634 mL 0.3170 mL 0.6341 mL 1.5852 mL
50 mM 0.0507 mL 0.2536 mL 0.5073 mL 1.2682 mL
60 mM 0.0423 mL 0.2114 mL 0.4227 mL 1.0568 mL
80 mM 0.0317 mL 0.1585 mL 0.3170 mL 0.7926 mL
100 mM 0.0254 mL 0.1268 mL 0.2536 mL 0.6341 mL
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HIV-1 inhibitor-48 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 inhibitor-48374067-85-3HIVReverse TranscriptaseHuman immunodeficiency virusnon-nucleoside reverse transcriptaseHIV strainsLAI100I103N181C188LInhibitorinhibitorinhibit

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