2. Metabolic Enzyme/Protease Anti-infection
  3. HIV Cytochrome P450 Reverse Transcriptase
  4. HIV-1 inhibitor-58

HIV-1 inhibitor-58 (Compound 10c) is a broad-spectrum antiviral agent. HIV-1 inhibitor-58 is a non-nucleoside reverse transcriptase inhibitor. HIV-1 inhibitor-58 inhibits WT strain IIIB, NNRTI-resistant strains (such as K103N and E138K) in MT-4 cells, with EC50 less than 50 nM. HIV-1 inhibitor-58 also inhibits CYP2C9 and CYP2C19 (IC50: 2.06 μM, 1.91 μM). HIV-1 inhibitor-58 can be used for HIV infection reserch.

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HIV-1 inhibitor-58 Chemical Structure

HIV-1 inhibitor-58 Chemical Structure

CAS No. : 3034064-68-8

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HIV-1 inhibitor-58 Related Antibodies

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HIV HIV-1 HIV-2

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Description

HIV-1 inhibitor-58 (Compound 10c) is a broad-spectrum antiviral agent. HIV-1 inhibitor-58 is a non-nucleoside reverse transcriptase inhibitor. HIV-1 inhibitor-58 inhibits WT strain IIIB, NNRTI-resistant strains (such as K103N and E138K) in MT-4 cells, with EC50 less than 50 nM. HIV-1 inhibitor-58 also inhibits CYP2C9 and CYP2C19 (IC50: 2.06 μM, 1.91 μM). HIV-1 inhibitor-58 can be used for HIV infection reserch[1].

Molecular Weight

452.51

Formula

C26H24N6O2
CAS No.
SMILES

CC1=CC(C#N)=CC(C)=C1OC2=C3CN(CCC3=NC(NC4=CC=C(C=C4)C#N)=N2)C(CC)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HIV-1 inhibitor-58 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 inhibitor-583034064-68-8HIVCytochrome P450Reverse TranscriptaseHuman immunodeficiency virusCYPsInfectionNNRTI-resistantK103NE138KCYP2C9HIV infectionMT-4 cellInhibitorinhibitorinhibit

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