2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. HSP70-IN-4

HSP70-IN-4 (Compound YM-01) is an Hsp70 inhibitor with an IC50 of 3.2 μM. HSP70-IN-4 is not BBB permeable.

For research use only. We do not sell to patients.

HSP70-IN-4 Chemical Structure

HSP70-IN-4 Chemical Structure

CAS No. : 1427450-47-2

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Other Forms of HSP70-IN-4:

HSP70-IN-4 Related Antibodies

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Description

HSP70-IN-4 (Compound YM-01) is an Hsp70 inhibitor with an IC50 of 3.2 μM. HSP70-IN-4 is not BBB permeable[1].

IC50 & Target[1]

HSP70

3.2 μM (IC50)

In Vitro

HSP70-IN-4 (Compound YM-01; 50 μM) significantly enhances the binding of Hsp70 to a misfolded protein[1].
HSP70-IN-4 (0-30 μM; 72 h) inhibits MDA-MB-231, MCF10A and MCF7 viability with EC50s of 2.0 ± 0.2, 3.3 ± 0.3 and 5.2 ± 0.8 μM, respectively[1].
HSP70-IN-4 is stable in water (at least 8 h at room temperature)[1].
HSP70-IN-4 is rapidly metabolized (t1/2 value of ∼2-4 min) in human liver microsomes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HSP70-IN-4 Related Antibodies

Cell Viability Assay[1]

Cell Line: MCF7, MCF10A and MDA-MB-231
Concentration: 0-30 μM
Incubation Time: 72 h
Result: Inhibited viability with EC50s of 2.0 ± 0.2, 3.3 ± 0.3 and 5.2 ± 0.8 μM for MDA-MB-231, MCF10A and MCF7, respectively.
In Vivo

HSP70-IN-4 (Compound YM-01) cannot pass the blood-brain barrier[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD1 mice[1]
Dosage: 20 mg/kg
Administration: Intravenous injection (Pharmacokinetic Analysis)
Result: Initial pharmacokinetics of HSP70-IN-4 (Compound YM-01; 20 mg/kg; i.v.)[1]
hour plasma (ng/mL) brain (ng/g) kidney (ng/g)
0.16 359 0 74378
1 324 0 63231
Molecular Weight

553.72

Formula

C27H27N3O4S3
CAS No.
SMILES

CN(C1=CC=CC=C1S/2)C2=C3C(N(CC)/C(S\3)=C/C4=[N+](C)C=CC=C4)=O.[O-]S(=O)(C5=CC=C(C)C=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HSP70-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSP70-IN-41427450-47-2HSPHeat shock proteinsblood-brain barrierBBBMDA-MB-231MCF10AMCF7Inhibitorinhibitorinhibit

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HY-18406
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