Human PD-L1 inhibitor V

Name: Human PD-L1 inhibitor V
Brand: MedChemExpress
SKU: HY-P2478
Rating: 4.5 (1 reviews)

Cat. No.: HY-P2478 Purity: 99.04%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Human PD-L1 inhibitor V, a human PD-1 protein binding peptide with a K_d value of 3.32 μM. Human PD-L1 inhibitor V inhibit the interaction of hPD-1/hPD-L1.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Human PD-L1 inhibitor V Chemical Structure

CAS No. : 2815311-61-4

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Human PD-L1 inhibitor V:

Human PD-L1 inhibitor V TFA Get quote

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Biological Activity
Purity & Documentation
References
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Description

Human PD-L1 inhibitor V, a human PD-1 protein binding peptide with a K_d value of 3.32 μM. Human PD-L1 inhibitor V inhibit the interaction of hPD-1/hPD-L1^[1].

IC₅₀ & Target

Kd: 3.32 μM (Human PD-1 protein)^[1]

In Vitro

Human PD-L1 inhibitor V (Ar5M_2) is a peptide designed with anchor residues Y56, R113, A121, D122 and Y123^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1485.71

Formula

C₆₅H₁₀₄N₂₀O₁₈S

CAS No.

2815311-61-4

Appearance

Solid

Color

White to off-white

Sequence

Leu-Asp-Tyr-Val-Asn-Arg-Arg-Lys-Met-Tyr-Gln

Sequence Shortening

LDYVNRRKMYQ

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Purity & Documentation

Purity: 99.04%

Select Batch:

Data Sheet (258 KB) SDS (252 KB)

COA (249 KB) RP-HPLC (108 KB) MS (191 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)

References

[1]. Qiao Li, et al. Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor. Oncotarget. 2016 Oct 4;7(40):64967-64976. [Content Brief]