2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. Hyp9

Hyp9 is a transient receptor potential canonical 6 (TRPC6)-specific agonist. Hyp9 can be used for the research of spinal cord injury (SCI).

For research use only. We do not sell to patients.

Hyp9 Chemical Structure

Hyp9 Chemical Structure

CAS No. : 3118-34-1

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Based on 2 publication(s) in Google Scholar

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Description

Hyp9 is a transient receptor potential canonical 6 (TRPC6)-specific agonist. Hyp9 can be used for the research of spinal cord injury (SCI)[1].

In Vitro

HYP9 (0, 1, 5, 10, 15, 20, 25, 30 µM; 72 h) inhibits astrocyte proliferation in a dose-dependent manner[1].
HYP9 dramatically suppresses AP4 overexpression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: CTX-TNA2 rat astrocytes
Concentration: 0, 1, 5, 10, 15, 20, 25, 30 µM
Incubation Time: 72 h
Result: Significantly inhibit astrocyte proliferation at 5-30 µM.
In Vivo

HP9 (intrathecally; 5 μg; 1, 3, 5, and 7 days) inhibits astrocyte activation and proliferation by inhibiting AQP4 in SCl rats in vivo models and that it preserves neuronal survival and functional recovery after SCI[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley Rats (180-220 g; adult female)[1]
Dosage: 5 μg
Administration: Intrathecally; 1, 3, 5, and 7 days
Result: Inhibited activation and proliferation of astrocytes in a rat SCI model.
Reduced apoptosis and promotes neuronal survival in SCI rats by TRPC6/AQP4 signaling pathway.
Facilitated functional motor recovery via TRPC6/AQP4 signaling pathway in SCI rats.
Molecular Weight

322.40

Formula

C18H26O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCCCC)C1=C(C=C(C(C(CCCCC)=O)=C1O)O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Hyp9 Related Classifications

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Keywords:

Hyp93118-34-1Hyp 9Hyp-9TRP ChannelTransient receptor potential channelstransient receptor potential canonical 6 (TRPC6)spinal cord injury (SCI)AQP4Inhibitorinhibitorinhibit

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