2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. DN401

DN401 is a potent TRAP1 inhibitor with an IC50 of 79 nM. DN401 shows a weak inhibition of Hsp90 (IC50 of 698 nM). DN401 inactivates mitochondrial TRAP1 and has potent anticancer activities.

For research use only. We do not sell to patients.

DN401 Chemical Structure

DN401 Chemical Structure

CAS No. : 2135749-60-7

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Based on 1 publication(s) in Google Scholar

DN401 Related Antibodies

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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Description

DN401 is a potent TRAP1 inhibitor with an IC50 of 79 nM. DN401 shows a weak inhibition of Hsp90 (IC50 of 698 nM). DN401 inactivates mitochondrial TRAP1 and has potent anticancer activities[1].

IC50 & Target[1]

TRAP1

79 nM (IC50)

HSP90

698 nM (IC50)

In Vitro

DN401 (5-20 µM; 24 hours) has superior cancer-specific cytotoxicity but reduced cytotoxic effects in normal cells[1].
DN401 (20 µM; 6 hours) inhibits the expression of Chk1 and Akt in HeLa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DN401 Related Antibodies

Cell Viability Assay[1]

Cell Line: HeLa, SK-HEP-1, T98G, H460, and PC3 cells
Concentration: 5 µM, 10 µM, 15 µM, 20 µM
Incubation Time: 24 hours
Result: Exhibited cytotoxic activity.

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 20 µM
Incubation Time: 6 hours
Result: Inhibited the expression of Chk1 and Akt.
In Vivo

DN401 (30 mg/kg; ip; once daily; for 14 days) reduces tumor growth and increases apoptotic cell death in tumor tissues, and does not cause weight loss or histologic abnormalities[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old BALB/c nu/nu male mice injected with PC3 cells[1]
Dosage: 30 mg/kg
Administration: ip; once daily; for 14 days
Result: Reduced tumor growth.
Molecular Weight

382.60

Formula

C13H9BrClN5O2
CAS No.
SMILES

NC1=NC(Cl)=C2C(N(N=C2)CC3=C(C=C4OCOC4=C3)Br)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DN401 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DN4012135749-60-7Panvotinib-401 Pan-401DN 401DN-401Panvotinib401Panvotinib 401Pan401Pan 401Pan-401HSPHeat shock proteinsTRAP1 InhibitorHsp90mitochondrial TRAP1anticancer activitiesInhibitorinhibitorinhibit

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