2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. DN401

DN401  (Synonyms: Panvotinib-401; Pan-401)

Cat. No.: HY-115781 Purity: 98.64%
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DN401 is a potent TRAP1 inhibitor with an IC50 of 79 nM. DN401 shows a weak inhibition of Hsp90 (IC50 of 698 nM). DN401 inactivates mitochondrial TRAP1 and has potent anticancer activities.

For research use only. We do not sell to patients.

DN401 Chemical Structure

DN401 Chemical Structure

CAS No. : 2135749-60-7

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1 mg USD 234 In-stock
5 mg USD 516 In-stock
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Based on 1 publication(s) in Google Scholar

DN401 Related Antibodies

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Description

DN401 is a potent TRAP1 inhibitor with an IC50 of 79 nM. DN401 shows a weak inhibition of Hsp90 (IC50 of 698 nM). DN401 inactivates mitochondrial TRAP1 and has potent anticancer activities[1].

IC50 & Target[1]

TRAP1

79 nM (IC50)

HSP90

698 nM (IC50)

In Vitro

DN401 (5-20 µM; 24 hours) has superior cancer-specific cytotoxicity but reduced cytotoxic effects in normal cells[1].
DN401 (20 µM; 6 hours) inhibits the expression of Chk1 and Akt in HeLa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DN401 Related Antibodies

Cell Viability Assay[1]

Cell Line: HeLa, SK-HEP-1, T98G, H460, and PC3 cells
Concentration: 5 µM, 10 µM, 15 µM, 20 µM
Incubation Time: 24 hours
Result: Exhibited cytotoxic activity.

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 20 µM
Incubation Time: 6 hours
Result: Inhibited the expression of Chk1 and Akt.
In Vivo

DN401 (30 mg/kg; ip; once daily; for 14 days) reduces tumor growth and increases apoptotic cell death in tumor tissues, and does not cause weight loss or histologic abnormalities[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old BALB/c nu/nu male mice injected with PC3 cells[1]
Dosage: 30 mg/kg
Administration: ip; once daily; for 14 days
Result: Reduced tumor growth.
Molecular Weight

382.60

Formula

C13H9BrClN5O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

NC1=NC(Cl)=C2C(N(N=C2)CC3=C(C=C4OCOC4=C3)Br)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 17.5 mg/mL (45.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6137 mL 13.0685 mL 26.1370 mL
5 mM 0.5227 mL 2.6137 mL 5.2274 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6137 mL 13.0685 mL 26.1370 mL 65.3424 mL
5 mM 0.5227 mL 2.6137 mL 5.2274 mL 13.0685 mL
10 mM 0.2614 mL 1.3068 mL 2.6137 mL 6.5342 mL
15 mM 0.1742 mL 0.8712 mL 1.7425 mL 4.3562 mL
20 mM 0.1307 mL 0.6534 mL 1.3068 mL 3.2671 mL
25 mM 0.1045 mL 0.5227 mL 1.0455 mL 2.6137 mL
30 mM 0.0871 mL 0.4356 mL 0.8712 mL 2.1781 mL
40 mM 0.0653 mL 0.3267 mL 0.6534 mL 1.6336 mL
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DN401 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DN4012135749-60-7Panvotinib-401 Pan-401DN 401DN-401Panvotinib401Panvotinib 401Pan401Pan 401Pan-401HSPHeat shock proteinsTRAP1 InhibitorHsp90mitochondrial TRAP1anticancer activitiesInhibitorinhibitorinhibit

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