2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Apoptosis Reactive Oxygen Species
  4. Iberverin

Iberverin  (Synonyms: 3-Methylthiopropyl isothiocyanate)

Cat. No.: HY-121204 Purity: ≥98.0%
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Iberverin (-Methylthiopropyl isothiocyanate) is a sulforaphane homolog. Iberverin has anticancer activity. Iberverin inhibits cell proliferation and migration. Iberverin induces mitochondrial-related apoptosis and intracellular reactive oxygen species.

For research use only. We do not sell to patients.

Iberverin Chemical Structure

Iberverin Chemical Structure

CAS No. : 505-79-3

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Based on 1 publication(s) in Google Scholar

Iberverin Related Antibodies

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  • Biological Activity

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Description

Iberverin (-Methylthiopropyl isothiocyanate) is a sulforaphane homolog. Iberverin has anticancer activity. Iberverin inhibits cell proliferation and migration. Iberverin induces mitochondrial-related apoptosis and intracellular reactive oxygen species[1].

In Vitro

Iberverin (0-200 μM, 48 h) inhibits the viability and proliferation of HCC cells, with IC50s less than 25 μM for Huh7, Huh7.5.1, and SNU739[1].
Iberverin (10 μM, 24-72 h) inhibits migration and invasion in Huh7, Huh7.5.1 and SNU739 cells[1].
Iberverin (40 μM, 12 h) induces mitochondrial-related apoptosis, induces DNA damage and causes G2/M cell cycle arrest in Huh7, Huh7.5.1 and SNU739 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Iberverin Related Antibodies

Western Blot Analysis[1]

Cell Line: Huh7, Huh7.5.1 and SNU739 cells
Concentration: 40 μM
Incubation Time: 12 h
Result: Enhanced the level of apoptotic protein Bax but repressed the expression of Bcl-2.
In Vivo

Iberverin (20 mg/kg, i.p., every 3 days for five cycles) inhibits the growth of HCC xenograft tumor in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Huh7.5.1 cells were subcutaneously injected into immunodeficient BALB/c nude mice[1]
Dosage: 20 mg/kg
Administration: i.p., every 3 days for five cycles
Result: Reduction the tumor size by 73.4% and weight by 55.3% of Huh7.5.1 xenograft tumors, with no systematic toxicity.
Decreased Ki-67 and PCNA level in tumor.
Molecular Weight

147.26

Formula

C5H9NS2
CAS No.
Appearance

Liquid (Density: 1.05±0.1 g/cm3)

Color

Colorless to light yellow

SMILES

CSCCCN=C=S
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (679.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7907 mL 33.9536 mL 67.9071 mL
5 mM 1.3581 mL 6.7907 mL 13.5814 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.7907 mL 33.9536 mL 67.9071 mL 169.7678 mL
5 mM 1.3581 mL 6.7907 mL 13.5814 mL 33.9536 mL
10 mM 0.6791 mL 3.3954 mL 6.7907 mL 16.9768 mL
15 mM 0.4527 mL 2.2636 mL 4.5271 mL 11.3179 mL
20 mM 0.3395 mL 1.6977 mL 3.3954 mL 8.4884 mL
25 mM 0.2716 mL 1.3581 mL 2.7163 mL 6.7907 mL
30 mM 0.2264 mL 1.1318 mL 2.2636 mL 5.6589 mL
40 mM 0.1698 mL 0.8488 mL 1.6977 mL 4.2442 mL
50 mM 0.1358 mL 0.6791 mL 1.3581 mL 3.3954 mL
60 mM 0.1132 mL 0.5659 mL 1.1318 mL 2.8295 mL
80 mM 0.0849 mL 0.4244 mL 0.8488 mL 2.1221 mL
100 mM 0.0679 mL 0.3395 mL 0.6791 mL 1.6977 mL
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Iberverin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Iberverin505-79-33-Methylthiopropyl isothiocyanateApoptosisReactive Oxygen SpeciesHCC,Huh7Huh7.5.1SNU739 cellliver cancerInhibitorinhibitorinhibit

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