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  4. Ibufenac

Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis.

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Ibufenac Chemical Structure

Ibufenac Chemical Structure

CAS No. : 1553-60-2

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Ibufenac Related Antibodies

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Description

Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis[1][2].

In Vitro

Ibufenac (60-500 μg/mL; duration of the experiment) has a corneal permeability coefficient of about 22 μcm/s[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ibufenac Related Antibodies
In Vivo

Ibufenac (10-80 mg/kg; p.o.; the experimental cycle is the time required to complete the erythema assessment) has an anti-inflammatory potency in the range of 2-4 times that of Aspirin (HY-14654) in the ultraviolet erythema experiment in guinea pigs[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (about 150 g weight), female guinea - pigs (500 - 800 g weight), male mice (20 - 25 g weight) for various inflammation - related models such as adjuvant arthritis in rats, formation of granulation tissue in the rat[2]
Dosage: 10, 20, 40, 80 mg/kg (adjuvant arthritis in rats); 80, 160, 320 mg/kg (formation of granulation tissue in the rat)
Administration: Oral administration (p.o.), twice a day (at 9:00 and 16:00 hr), and the cycle varied according to different experiments, for example, 7 days for the formation of granulation tissue experiment in the rat, 19 days for the adjuvant arthritis experiment in the rat after injection of adjuvant
Result: Was twice as active as aspirin but less effective than phenylbutazone in suppressing the development of adjuvant arthritis in the adjuvant arthritis experiment in rats.
Produced a significant reduction in granulation tissue compared with controls, but the effect was more modest compared to hydrocortisone sodium succinate in the formation of granulation tissue experiment in the rat (160 and 320 mg/kg).
Molecular Weight

192.26

Formula

C12H16O2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(O)CC1=CC=C(CC(C)C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (520.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2013 mL 26.0067 mL 52.0134 mL
5 mM 1.0403 mL 5.2013 mL 10.4027 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.98%

SDS (393 KB)

COA (243 KB) HNMR (130 KB) RP-HPLC (260 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.2013 mL 26.0067 mL 52.0134 mL 130.0336 mL
5 mM 1.0403 mL 5.2013 mL 10.4027 mL 26.0067 mL
10 mM 0.5201 mL 2.6007 mL 5.2013 mL 13.0034 mL
15 mM 0.3468 mL 1.7338 mL 3.4676 mL 8.6689 mL
20 mM 0.2601 mL 1.3003 mL 2.6007 mL 6.5017 mL
25 mM 0.2081 mL 1.0403 mL 2.0805 mL 5.2013 mL
30 mM 0.1734 mL 0.8669 mL 1.7338 mL 4.3345 mL
40 mM 0.1300 mL 0.6502 mL 1.3003 mL 3.2508 mL
50 mM 0.1040 mL 0.5201 mL 1.0403 mL 2.6007 mL
60 mM 0.0867 mL 0.4334 mL 0.8669 mL 2.1672 mL
80 mM 0.0650 mL 0.3251 mL 0.6502 mL 1.6254 mL
100 mM 0.0520 mL 0.2601 mL 0.5201 mL 1.3003 mL
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Ibufenac Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ibufenac1553-60-2DytransinCOXCyclooxygenasenon-steroidalanti-rheumatoidanalgesicanti-inflammatoryInhibitorinhibitorinhibit

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