2. Metabolic Enzyme/Protease
  3. Aldose Reductase
  4. IDD388

IDD388 is a selective aldose reductase (ALR2) inhibitor with an IC50 of 30 nM. IDD388 displays selectivity for ALR2 over ALR1 (IC50 of 14 μM).

For research use only. We do not sell to patients.

IDD388 Chemical Structure

IDD388 Chemical Structure

CAS No. : 314297-26-2

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5 mg USD 350 In-stock
10 mg USD 560 In-stock
25 mg USD 980 In-stock
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Based on 1 publication(s) in Google Scholar

IDD388 Related Antibodies

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Description

IDD388 is a selective aldose reductase (ALR2) inhibitor with an IC50 of 30 nM. IDD388 displays selectivity for ALR2 over ALR1 (IC50 of 14 μM)[1].

IC50 & Target

IC50: 30 nM (ALR2)[1]
Molecular Weight

416.63

Formula

C16H12BrClFNO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(COC1=CC(Cl)=CC=C1C(NCC2=CC=C(C=C2F)Br)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (300.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4002 mL 12.0011 mL 24.0021 mL
5 mM 0.4800 mL 2.4002 mL 4.8004 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4002 mL 12.0011 mL 24.0021 mL 60.0053 mL
5 mM 0.4800 mL 2.4002 mL 4.8004 mL 12.0011 mL
10 mM 0.2400 mL 1.2001 mL 2.4002 mL 6.0005 mL
15 mM 0.1600 mL 0.8001 mL 1.6001 mL 4.0004 mL
20 mM 0.1200 mL 0.6001 mL 1.2001 mL 3.0003 mL
25 mM 0.0960 mL 0.4800 mL 0.9601 mL 2.4002 mL
30 mM 0.0800 mL 0.4000 mL 0.8001 mL 2.0002 mL
40 mM 0.0600 mL 0.3000 mL 0.6001 mL 1.5001 mL
50 mM 0.0480 mL 0.2400 mL 0.4800 mL 1.2001 mL
60 mM 0.0400 mL 0.2000 mL 0.4000 mL 1.0001 mL
80 mM 0.0300 mL 0.1500 mL 0.3000 mL 0.7501 mL
100 mM 0.0240 mL 0.1200 mL 0.2400 mL 0.6001 mL
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IDD388 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDD388314297-26-2IDD 388IDD-388Aldose ReductaseALR2 inhibitorInhibitorinhibitorinhibit

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