2. PI3K/Akt/mTOR Autophagy
  3. PI3K Autophagy
  4. Idelalisib-d5

Idelalisib-d5  (Synonyms: CAL-101 d5; GS-1101 d5)

Cat. No.: HY-13026S Purity: 98.35%
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Idelalisib-d5 is a deuterium labeled Idelalisib. Idelalisib is a highly selective and orally bioavailable p110δ inhibitor[1].

For research use only. We do not sell to patients.

Idelalisib-d<sub>5</sub> Chemical Structure

Idelalisib-d5 Chemical Structure

CAS No. : 1830330-31-8

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1 mg USD 420 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Idelalisib-d5:

Idelalisib-d5 Related Antibodies

Top Publications Citing Use of Products

View All PI3K Isoform Specific Products:

View All Isoforms
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Idelalisib-d5 is a deuterium labeled Idelalisib. Idelalisib is a highly selective and orally bioavailable p110δ inhibitor[1].

IC50 & Target

P110δ inhibitor
Molecular Weight

420.45

Formula

C22H13D5FN7O
CAS No.
Unlabeled CAS

870281-82-6
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C([C@@H](NC3=C4N=CNC4=NC=N3)CC)=NC5=C1C(F)=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : ≥ 30 mg/mL (71.35 mM)

DMF : ≥ 30 mg/mL (71.35 mM)

DMSO : ≥ 25 mg/mL (59.46 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 25 mg/mL (59.46 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 15 mg/mL (35.68 mM)

Ethanol : ≥ 15 mg/mL (35.68 mM)

DMF:PBS (pH 7.2) (1:1) : ≥ 0.5 mg/mL (1.19 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3784 mL 11.8920 mL 23.7840 mL
5 mM 0.4757 mL 2.3784 mL 4.7568 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF:PBS (pH 7.2) (1:1) / Ethanol / Ethanol / DMSO / DMSO / DMF / DMF 1 mM 2.3784 mL 11.8920 mL 23.7840 mL 59.4601 mL
Ethanol / Ethanol / DMSO / DMSO / DMF / DMF 5 mM 0.4757 mL 2.3784 mL 4.7568 mL 11.8920 mL
10 mM 0.2378 mL 1.1892 mL 2.3784 mL 5.9460 mL
15 mM 0.1586 mL 0.7928 mL 1.5856 mL 3.9640 mL
20 mM 0.1189 mL 0.5946 mL 1.1892 mL 2.9730 mL
25 mM 0.0951 mL 0.4757 mL 0.9514 mL 2.3784 mL
30 mM 0.0793 mL 0.3964 mL 0.7928 mL 1.9820 mL
DMSO / DMSO / DMF / DMF 40 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4865 mL
50 mM 0.0476 mL 0.2378 mL 0.4757 mL 1.1892 mL
DMF / DMF 60 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9910 mL
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Idelalisib-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Idelalisib-d51830330-31-8CAL-101 d5GS-1101 d5PI3KAutophagyPhosphoinositide 3-kinasep110δInhibitorinhibitorinhibit

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