IDH1/2-IN-1 

IDH1/2-IN-1 (Compound 6b) serves as a dual inhibitor of IDH1(R132H)/IDH2(R140Q) with IC₅₀ values of 0.22 μM and 1.6 μM, respectively. IDH1/2-IN-1 effectively inhibits tumor growth by suppressing tumor cell proliferation and enhancing host defense through the activation of antioxidant enzymes. Additionally, IDH1/2-IN-1 reduces inflammation and promotes apoptosis, demonstrating robust antitumor activity. IDH1/2-IN-1 holds potential for research in leukemia^[1].

IC50: 0.22 μM (IDH1(R132H))^[1].
IC50: 1.6 μM (IDH2(R140Q))^[1].

IDH1/2-IN-1 (Compound 6b) exhibits superior antitumor activity against THP1 and Kasumi leukemia cancer cells with IC₅₀ values of 10.7 μM and 10 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

580.62

C₂₆H₂₈N₈O₆S

O=S(C1=CC=C(NC2=NC(NC3=CC=C(OC)C=C3)=NC(N/N=C/C4=CC(OC)=C(OC)C(OC)=C4)=N2)C=C1)(N)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tawfik H O, et al. Rationale design of novel substituted 1, 3, 5-triazine candidates as dual IDH1 (R132H)/IDH2 (R140Q) inhibitors with high selectivity against acute myeloid leukemia: In vitro and in vivo preclinical investigations[J]. Bioorganic Chemistry, 2024, 149: 107483.  [Content Brief]