IDO1-IN-21

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IDO1-IN-21 (compound 10m) is an IDO1 inhibitor (IC₅₀ = 0.64 μM). IDO1-IN-21 effectively inhibits tumor growth in mice.

For research use only. We do not sell to patients.

IDO1-IN-21 Chemical Structure

CAS No. : 2892432-98-1

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Biological Activity
Purity & Documentation
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Description

IDO1-IN-21 (compound 10m) is an IDO1 inhibitor (IC₅₀ = 0.64 μM). IDO1-IN-21 effectively inhibits tumor growth in mice^[1].

IC₅₀ & Target^[1]

IDO1

0.64 μM (IC₅₀)

In Vitro

IDO1-IN-21 (0-50 μM; 48 h) inhibits the viability of SW480 cells with an IC₅₀ value of 28.64 μM^[1].
IDO1-IN-21 (0-10 μM; 48 h) inhibits the IDO1 of HeLa cells with an IC₅₀ value of 1.04 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	SW480 cells
Concentration:	0-50 μM
Incubation Time:	48 h
Result:	Surpressed viability of SW480 cells (IC₅₀ = 28.64 μM).

In Vivo

IDO1-IN-21 (50, 100 mg/kg; i.p.; every three day for 21 consecutive days) inhibits growth of tumor in CT26 tumor-bearing mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CT26 tumor-bearing mice^[1].
Dosage:	50, 100 mg/kg
Administration:	Intraperitoneal administration; every three day for 21 consecutive days.
Result:	Led to significant suppression of tumor growth.

Molecular Weight

479.45

Formula

C₂₁H₁₉F₂N₃O₆S

CAS No.

2892432-98-1

SMILES

O/N=C1C2=CC=C(OC)C=C2OC(C(N3CCN(CC3)S(=O)(C4=CC(F)=C(C=C4)F)=O)=O)=C\1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang K, et al. Discovery of novel sulfonamide chromone-oxime derivatives as potent indoleamine 2,3-dioxygenase 1 inhibitors. Eur J Med Chem. 2023 Jun 5;254:115349. [Content Brief]

IDO1-IN-21 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDO1-IN-212892432-98-1Indoleamine 2,3-Dioxygenase (IDO)tumorcancerSW480 cellsHeLa cellsInhibitorinhibitorinhibit

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