Idroxioleic acid (Synonyms: (R)-2-Hydroxyoleic acid; (R)-2-OHOA; (R)-LAM561)

Cat. No.: HY-139784: FAQs
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Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA), the R enantiomer of (Rac)-Idroxioleic acid, is an orally active fatty acid that modulates the lipid composition and structure of the membranes. Idroxioleic acid has antitumor activities.

For research use only. We do not sell to patients.

Idroxioleic acid Chemical Structure

CAS No. : 182370-45-2

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Other Forms of Idroxioleic acid:

(Rac)-Idroxioleic acid Get quote

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Description

In Vitro

Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA) inhibited the growth of A549, lung adenocarcinoma cell line with an IC₅₀ of 252 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA; 400 mg/kg; p.o.; daily; for 21 days) causes a reduction in tumor volume of about 20-25% after 21 days^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male NUDE (Swiss) Crl:NU(Ico)-Foxn1nu mice (5 weeks old, 30-35 g) injected with A549 human lung cancer cells^[1]
Dosage:	400 mg/kg
Administration:	p.o.; daily; for 21 days
Result:	Caused a reduction in tumor volume of about 20-25% after 21 days.

Clinical Trial

Molecular Weight

298.46

Formula

C₁₈H₃₄O₃

CAS No.

182370-45-2

SMILES

OC([C@H](O)CCCCCC/C=C\CCCCCCCC)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Stefano Piotto, et al. Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets. Biochim Biophys Acta. 2014 Jun;1838(6):1628-37. [Content Brief]

Idroxioleic acid Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Idroxioleic acid182370-45-2(R)-2-Hydroxyoleic acid (R)-2-OHOA (R)-LAM561OthersorallyantitumorlipidcompositionmembranesInhibitorinhibitorinhibit

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