MK-761 free base

Cat. No.: HY-123449: FAQs
Data Sheet SDS COA Handling Instructions

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MK-761 free base is a potent and orally active β2-adrenergic blocker. MK-761 free base shows antihypertensive and positive inotropic effects. MK-761 free base shows vasodilating properties.

For research use only. We do not sell to patients.

MK-761 free base Chemical Structure

CAS No. : 65321-41-7

Size	Price	Stock
5 mg	USD 359	Ask For Quote & Lead Time
10 mg	USD 597	Ask For Quote & Lead Time
25 mg	USD 1225	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
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Description

MK-761 free base is a potent and orally active β2-adrenergic blocker. MK-761 free base shows antihypertensive and positive inotropic effects. MK-761 free base shows vasodilating properties^[1].

IC₅₀ & Target^[1]

Beta-2 adrenergic receptor

Molecular Weight

249.31

Formula

C₁₃H₁₉N₃O₂

CAS No.

65321-41-7

Appearance

Solid

Color

Off-white to light yellow

SMILES

N#CC1=CC=CN=C1OC[C@H](CNC(C)(C)C)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (401.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0111 mL	20.0554 mL	40.1107 mL
5 mM	0.8022 mL	4.0111 mL	8.0221 mL
10 mM	0.4011 mL	2.0055 mL	4.0111 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (248 KB) HNMR (135 KB) RP-HPLC (257 KB) LCMS (108 KB)

Handling Instructions (2659 KB)

References

[1]. Scriabine A, et al. Antihypertensive and cardiac effects of two novel beta-adrenoceptor blocking drugs. Experientia. 1979 Dec 15;35(12):1634-7. [Content Brief]

[2]. C.S. Sweet, et al. Peripheral Vasodilator and β-Adrenoceptor Blocking Properties of Several β-Adrenoceptor Antagonists. Clinical and Experimental Hypertension. 2009, 449-471.

[3]. Sweet CS, et al. Beta adrenoceptor blocking properties of MK-761. J Pharmacol Exp Ther. 1979 Oct;211(1):195-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.0111 mL	20.0554 mL	40.1107 mL	100.2768 mL
	5 mM	0.8022 mL	4.0111 mL	8.0221 mL	20.0554 mL
	10 mM	0.4011 mL	2.0055 mL	4.0111 mL	10.0277 mL
	15 mM	0.2674 mL	1.3370 mL	2.6740 mL	6.6851 mL
	20 mM	0.2006 mL	1.0028 mL	2.0055 mL	5.0138 mL
	25 mM	0.1604 mL	0.8022 mL	1.6044 mL	4.0111 mL
	30 mM	0.1337 mL	0.6685 mL	1.3370 mL	3.3426 mL
	40 mM	0.1003 mL	0.5014 mL	1.0028 mL	2.5069 mL
	50 mM	0.0802 mL	0.4011 mL	0.8022 mL	2.0055 mL
	60 mM	0.0669 mL	0.3343 mL	0.6685 mL	1.6713 mL
	80 mM	0.0501 mL	0.2507 mL	0.5014 mL	1.2535 mL
	100 mM	0.0401 mL	0.2006 mL	0.4011 mL	1.0028 mL

MK-761 free base Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-76165321-41-7MK761MK 761Adrenergic ReceptorBeta Receptororally activeantihypertensivevasodilating propertiesInhibitorinhibitorinhibit

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