2. NF-κB
  3. IKK
  4. IKK2-IN-3

IKK2-IN-3 (Compound 8) is an IKK2 inhibitor with an IC50 of 0.075 μM.

For research use only. We do not sell to patients.

IKK2-IN-3 Chemical Structure

IKK2-IN-3 Chemical Structure

CAS No. : 916985-21-2

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Based on 1 publication(s) in Google Scholar

IKK2-IN-3 Related Antibodies

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IKK-α IKK-β IKK IKKε TBK1

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Description

IKK2-IN-3 (Compound 8) is an IKK2 inhibitor with an IC50 of 0.075 μM[1].

IC50 & Target

IKK2

0.075 μM (IC50)

Molecular Weight

487.55

Formula

C22H21N3O6S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(OCC2=CC=C(S(=O)(C)=O)C=C2)C=C(N3C4=CC(OC)=C(OC)C=C4N=C3)S1)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (20.51 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0511 mL 10.2554 mL 20.5107 mL
5 mM 0.4102 mL 2.0511 mL 4.1021 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0511 mL 10.2554 mL 20.5107 mL 51.2768 mL
5 mM 0.4102 mL 2.0511 mL 4.1021 mL 10.2554 mL
10 mM 0.2051 mL 1.0255 mL 2.0511 mL 5.1277 mL
15 mM 0.1367 mL 0.6837 mL 1.3674 mL 3.4185 mL
20 mM 0.1026 mL 0.5128 mL 1.0255 mL 2.5638 mL
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IKK2-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IKK2-IN-3916985-21-2IKKIκB kinaseI kappa B kinaseinflammatory disorderscancerInhibitorinhibitorinhibit

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