2. NF-κB
  3. IKK
  4. IKKβ-IN-3

IKKβ-IN-3 (Compound hit4) is a IKKβ inhibitor with an IC50 value of 30.4 nM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases. IKKβ-IN-3 can be used in the study of CAF-induced arthritis.

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IKKβ-IN-3 Chemical Structure

IKKβ-IN-3 Chemical Structure

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IKKβ-IN-3 Related Antibodies

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IKK-α IKK-β IKK IKKε TBK1

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Description

IKKβ-IN-3 (Compound hit4) is a IKKβ inhibitor with an IC50 value of 30.4 nM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases. IKKβ-IN-3 can be used in the study of CAF-induced arthritis[1].

IC50 & Target

IKKβ

30.4 nM (IC50)

In Vivo

IKKβ-IN-3 (Compound hit4) (10, 30 mg/kg; 1 dose, 14 days) can reduce inflammation in complete Freund’s adjuvant-induced arthriti (AIA) rat model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adjuvant-induced arthritis (AIA) rat model[1]
Dosage: 10 and 30 mg/kg
Administration: gastric gavage (i.g.)
Result: At 30 mg/kg, significantly reduced rat paw swelling, inflammatory cell infiltration and hyperemia of the synovium.
Animal Model:
Dosage:
Administration:
Result:
Molecular Weight

321.41

Formula

C18H27NO4
SMILES

CC(C[C@H](NC(C[C@H](CC(CC1=CC=CC=C1)=O)O)=O)CO)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IKKβ-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IKKβ-IN-3IKKIκB kinaseI kappa B kinaseadjuvant-induced arthritis rat models， joint inflammationInhibitorinhibitorinhibit

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