IKKβ-IN-3

Cat. No.: HY-163412: FAQs
Data Sheet Handling Instructions

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IKKβ-IN-3 (Compound hit4) is a IKKβ inhibitor with an IC₅₀ value of 30.4 nM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases. IKKβ-IN-3 can be used in the study of CAF-induced arthritis.

For research use only. We do not sell to patients.

IKKβ-IN-3 Chemical Structure

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IKK-α IKK-β IKK IKKε TBK1

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IKKβ

30.4 nM (IC₅₀)

In Vivo

IKKβ-IN-3 (Compound hit4) (10, 30 mg/kg; 1 dose, 14 days) can reduce inflammation in complete Freund’s adjuvant-induced arthriti (AIA) rat model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adjuvant-induced arthritis (AIA) rat model^[1]
Dosage:	10 and 30 mg/kg
Administration:	gastric gavage (i.g.)
Result:	At 30 mg/kg, significantly reduced rat paw swelling, inflammatory cell infiltration and hyperemia of the synovium.

Animal Model:
Dosage:
Administration:
Result:

Molecular Weight

321.41

Formula

C₁₈H₂₇NO₄

SMILES

CC(C[C@H](NC(C[C@H](CC(CC1=CC=CC=C1)=O)O)=O)CO)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li L, et al. The discovery of a novel IκB kinase β inhibitor based on pharmacophore modeling, virtual screening and biological evaluation. Future Med Chem. 2024;16(6):531-544. [Content Brief]

IKKβ-IN-3 Related Classifications

Inflammation/Immunology

NF-κB
IKK

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IKKβ-IN-3IKKIκB kinaseI kappa B kinaseadjuvant-induced arthritis rat models， joint inflammationInhibitorinhibitorinhibit

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