IM-250

Cat. No.: HY-150306 Purity: 99.94%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

IM-250 is an orally active helicase-primase inhibitor. IM-250 is effective against HSV infection. IM-250 inhibits HSV-1 infection in Vero cells (IC₅₀: ~20 nM).

For research use only. We do not sell to patients.

IM-250 Chemical Structure

CAS No. : 2305750-23-4

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IM-250 is an orally active helicase-primase inhibitor. IM-250 is effective against HSV infection. IM-250 inhibits HSV-1 infection in Vero cells (IC₅₀: ~20 nM)^[1]^[2].

Molecular Weight

435.51

Formula

C₂₀H₁₉F₂N₃O₂S₂

CAS No.

2305750-23-4

Appearance

Solid

Color

White to off-white

SMILES

FC(C=CC(F)=C1)=C1C(C=C2)=CC=C2CC(N(C3=NC(C)=C([S@@](C)(=N)=O)S3)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (287.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2962 mL	11.4808 mL	22.9616 mL
5 mM	0.4592 mL	2.2962 mL	4.5923 mL
10 mM	0.2296 mL	1.1481 mL	2.2962 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.94%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (247 KB) HNMR (261 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Bernstein DI, et al. Intermittent therapy with helicase-primase inhibitor IM-250 efficiently controls recurrent herpes disease and reduces reactivation of latent HSV. Antiviral Res. 2023 Nov;219:105733. [Content Brief]

[2]. Uhlig N, et al. Helicase primase inhibitors (HPIs) are efficacious for therapy of human herpes simplex virus (HSV) disease in an infection mouse model. Antiviral Res. 2021 Nov;195:105190. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2962 mL	11.4808 mL	22.9616 mL	57.4040 mL
	5 mM	0.4592 mL	2.2962 mL	4.5923 mL	11.4808 mL
	10 mM	0.2296 mL	1.1481 mL	2.2962 mL	5.7404 mL
	15 mM	0.1531 mL	0.7654 mL	1.5308 mL	3.8269 mL
	20 mM	0.1148 mL	0.5740 mL	1.1481 mL	2.8702 mL
	25 mM	0.0918 mL	0.4592 mL	0.9185 mL	2.2962 mL
	30 mM	0.0765 mL	0.3827 mL	0.7654 mL	1.9135 mL
	40 mM	0.0574 mL	0.2870 mL	0.5740 mL	1.4351 mL
	50 mM	0.0459 mL	0.2296 mL	0.4592 mL	1.1481 mL
	60 mM	0.0383 mL	0.1913 mL	0.3827 mL	0.9567 mL
	80 mM	0.0287 mL	0.1435 mL	0.2870 mL	0.7175 mL
	100 mM	0.0230 mL	0.1148 mL	0.2296 mL	0.5740 mL

IM-250 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IM-2502305750-23-4IM250IM 250HSVHerpes simplex virusHSV infection Vero cellInhibitorinhibitorinhibit

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